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ALL Panel by FISH (Adult) : 1001112
MessageThis ALL Panel should be ordered for an adult.
Test Code
MDFCPCALLAP or 1001112
Alias/See Also
acute lymphoblastic leukemia panel
CPT Codes
88271x7, 88275x3
Includes
Panel includes: MLL gene rearrangement (11q23), BCR/ABL1 translocation, t(9;22), TEL/AML1 translocation, t(12;21), Aneuploidy 6, 21.
Instructions
Bone Marrow aspirate in a green top sodium heparin tube (2-3 mL) or Peripheral Blood in a green top sodium heparin tube (2-10 mL).
Transport Container
Blood or Bone Marrow: Do not centrifuge.
Transport Temperature
Blood or Bone Marrow: Ambient temperature within 24 hours. Specimen can be refrigerated if not transported immediately. Do not freeze. Protect from heat with a cold pack.
Specimen Stability
Blood and Bone Marrow: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable
Methodology
Fluorescence in situ hybridization (FISH)
Setup Schedule
Monday - Friday
Report Available
Up to 7 days
1-2 days for new diagnosis
1-2 days for new diagnosis
Limitations
Laboratory test results should always be considered in the context of clinical observations. This test was developed and its performance characteristics determined by med fusion. It has not been cleared or approved by the U.S. Food and Drug
Administration (FDA). The FDA has determined that such clearance or approval is not necessary. This test is used for clinical purposes. It should not be regarded as investigational for research. This laboratory is certified under the Clinical Laboratory Improvement
Amendments of 1988 (CLIA) as qualified to perform high complexity clinical laboratory testing.
Administration (FDA). The FDA has determined that such clearance or approval is not necessary. This test is used for clinical purposes. It should not be regarded as investigational for research. This laboratory is certified under the Clinical Laboratory Improvement
Amendments of 1988 (CLIA) as qualified to perform high complexity clinical laboratory testing.
Reference Range
An interpretive report will be provided.
Clinical Significance
B-Cell Acute lymphoblastic lymphoma (B-ALL) is characterized by recurrent genetic abnormalities including balanced translocations and other chromosomal abnormalities. B-ALL is classified into different subtypes based on the presence and absence of chromosomal changes. Most common cytogenetic findings in pediatric B-ALL are t(9;22)(q34;q11.2) and t(12;21)(p13;q22). The t(12;21)(p13;q22) is a cryptic translocation resulting in TEL/AML1 gene fusion and can only be detected by FISH studies. Detection of TEL/AML1 gene fusion is associated with a good prognosis in contrast with the presence of t(9;22) which is a marker for bad prognosis. Hyperdiploid pediatric B-ALL contains a numerical increase in chromosomes, usually without structural abnormalities. Extra copies of chromosomes are non- random and reportedly, simultaneous trisomies for chromosomes 4, 10 and 17 are associated with the best prognosis.
Performing Laboratory
med fusion
