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Antistreptolysin-O Antibody (ASO) : 265
Test CodeASOQ or 265
Alias/See Also
Streptolysin-O Antibody, Strep A, ASO, Streptococcus, Group A, Strep
CPT Codes
86060
Instructions
Overnight fasting is preferred.
Plain red orserum separator tube.
Plain red orserum separator tube.
Transport Container
Centrifuge the serum separator tube and transport. If plain red, centrifuge and aliquot 1 mL serum or plasma (Min: 0.5 mL) into a standard transport tube.
Transport Temperature
Refrigerated.
Specimen Stability
Ambient: 72 hours; Refrigerated: 5 days; Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis.
Methodology
Immunoturbidimetric
Setup Schedule
Tuesday - Saturday
Report Available
2-4 days (From receipt at performing laboratory)
Limitations
False-positive ASO titers can be due to increased levels of serum beta-lipoprotein produced in liver disease and by "contamination" of serum by Bacillus cereus and Pseudomonas species. ASO is not sensitive for the diagnosis of streptococcal pyoderma.
Reference Range
| Effective 4-2-2018 less than 5 years less than 100 IU/mL 5 to 20 years less than 250 IU/mL greater than or equal to 21 years less than 200 IU/mL |
Clinical Significance
This test is a sensitive test for recent streptococcal infection. A rise in ASO begins about one week after infection and peaks two to four weeks later. ASO levels do not rise with cutaneous infections. In the absence of complications or reinfection, the ASO level will fall to preinfection levels within 6 to 12 months. Over 80% of patients with acute rheumatic fever and 95% of patients with acute glomerulonephritis due to streptococci have elevated levels of ASO.
Performing Laboratory
Quest Diagnostics
