Porphyrins, Fractionation, Quantitative 24-Hour Urine : 729

Test Code
UPOF24 or 729

Alias/See Also

CPT Codes

Panel includes: Coproporphyrin I, Coproporphyrin III, Heptacarboxyporphyrin, Hexacarboxyporphyrin, Pentacarboxyporphyrin, Uroporphyrin I, Uroporphyrin III, Total Porphyrins

24-hour urine. Refrigerate 24-hour specimens during collection. Protect from light.

Transport Container
Protect from light. Transfer 2 mL aliquot from well mixed 24-hour urine to an amber transport tube (preferred) or protect the container from light with foil or place in an amber bag. (Min: 1 mL) Record total volume and collection time interval on transport tube and test request form.

Transport Temperature

Specimen Stability
Ambient: Unacceptable; Refrigerated: 7 days; Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature. Not protected from light. Samples with a pH less than 4.0.

High Performance Liquid Chromatography (HPLC)

Setup Schedule
Tuesday - Saturday

Report Available
1-5 days (From receipt at performing laboratory)

Reference Range
Porphyrins, Fractionated, 24-Hour Urine:
Uroporphyrin I                  4.1-22.4 mcg/24 h
Uroporphyrin III                0.7-7.4 mcg/24 h
Heptacarboxyporphyrin    less than or equal to 3.3 mcg/24 h
Hexacarboxyporphyrin     less than or equal to 10 mcg/24 h
Pentacarboxyporphyrin    less than or equal to 4.6 mcg/24 h
Coproporphyrin I                7.1-48.7 mcg/24 h
Coproporphyrin III             11.0-148.5 mcg/24 h
Total Porphyrins                 35-210.7 mcg/24 h 

Clinical Significance
Porphyria is a group of distinct disorders characterized by the abnormal accumulation of porphyrins or porphyrin precursors. Porphyrin Fractionation of Urine is useful in diagnosing porphyrin cutanea tarda, hereditary coproporphyria, and variegate porphyria.

Performing Laboratory
Quest Diagnostics

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.