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Porphyrins, Fractionation, Quantitative 24-Hour Urine : 729
Test CodeUPOF24 or 729
Alias/See Also
Porphyria
CPT Codes
84120
Includes
Panel includes: Coproporphyrin I, Coproporphyrin III, Heptacarboxyporphyrin, Hexacarboxyporphyrin, Pentacarboxyporphyrin, Uroporphyrin I, Uroporphyrin III, Total Porphyrins
Instructions
24-hour urine. Refrigerate 24-hour specimens during collection. Protect from light.
Transport Container
Protect from light. Transfer 2 mL aliquot from well mixed 24-hour urine to an amber transport tube (preferred) or protect the container from light with foil or place in an amber bag. (Min: 1 mL) Record total volume and collection time interval on transport tube and test request form.
Transport Temperature
Refrigerated.
Specimen Stability
Ambient: Unacceptable; Refrigerated: 7 days; Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature. Not protected from light. Samples with a pH less than 4.0.
Methodology
High Performance Liquid Chromatography (HPLC)
Setup Schedule
Tuesday - Saturday
Report Available
1-5 days (From receipt at performing laboratory)
Reference Range
| Porphyrins, Fractionated, 24-Hour Urine: Uroporphyrin I 4.1-22.4 mcg/24 h Uroporphyrin III 0.7-7.4 mcg/24 h Heptacarboxyporphyrin less than or equal to 3.3 mcg/24 h Hexacarboxyporphyrin less than or equal to 10 mcg/24 h Pentacarboxyporphyrin less than or equal to 4.6 mcg/24 h Coproporphyrin I 7.1-48.7 mcg/24 h Coproporphyrin III 11.0-148.5 mcg/24 h Total Porphyrins 35-210.7 mcg/24 h |
Clinical Significance
Porphyria is a group of distinct disorders characterized by the abnormal accumulation of porphyrins or porphyrin precursors. Porphyrin Fractionation of Urine is useful in diagnosing porphyrin cutanea tarda, hereditary coproporphyria, and variegate porphyria.
Performing Laboratory
Quest Diagnostics
