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Thyroxine Binding Globulin (TBG) : 870
Test CodeTBGLOB or 870
Alias/See Also
TBG
CPT Codes
84442
Instructions
Serum separator tube.
Transport Container
Centrifuge the serum separator tube and transport, 1 mL serum. (Min: 0.5 mL)
Transport Temperature
Refrigerated.
Specimen Stability
Ambient: 7 days; Refrigerated: 7 days; Frozen: 28 days
Methodology
Immunoassay (IA)
Setup Schedule
Wednesday
Report Available
2-8 days (From receipt at performing laboratory)
Reference Range
Adult Male 12.7-25.1 mcg/mL
Adult Female 13.5-30.9 mcg/mL
Pediatric
4-6 Years 14.8-32.9 mcg/mL
7-8 Years 16.3-30.7 mcg/mL
9-10 Years 15.8-27.4 mcg/mL
11 Years 15.5-27.4 mcg/mL
12 Years 14.8-26.2 mcg/mL
13 Years 13.8-25.2 mcg/mL
14 Years 12.2-25.2 mcg/mL
15 Years 10.8-23.8 mcg/mL
16 Years 10.0-23.8 mcg/mL
17 Years 8.5-23.1 mcg/mL
Adult Female 13.5-30.9 mcg/mL
Pediatric
4-6 Years 14.8-32.9 mcg/mL
7-8 Years 16.3-30.7 mcg/mL
9-10 Years 15.8-27.4 mcg/mL
11 Years 15.5-27.4 mcg/mL
12 Years 14.8-26.2 mcg/mL
13 Years 13.8-25.2 mcg/mL
14 Years 12.2-25.2 mcg/mL
15 Years 10.8-23.8 mcg/mL
16 Years 10.0-23.8 mcg/mL
17 Years 8.5-23.1 mcg/mL
Clinical Significance
Thyroxine-binding globulin (TBG), a glycoprotein produced in the liver, binds both thyroxine (T4) and triiodothyronine (T3) with high affinity. Because TBG accounts for 76% of plasma protein thyroxine-binding activity, an increase or decrease in its circulating level alters total concentrations of T4 and T3 in blood, leading to potential confusion with true thyroid gland dysfunction. A number of diseases and medications, as well as inherited alterations in TBG gene expression, can change the serum TBG concentration. Measurement of TBG is useful in distinguishing quantitative TBG derangements from thyroid dysfunction. This analyte is elevated with estrogen therapy (especially oral contraceptive agents), during pregnancy and or hepatitis. Serum TBG may be decreased in cirrhosis, in the nephritic syndrome and by androgens.
Performing Laboratory
Quest Diagnostics