D13S319 (13q13.4) deletion by FISH : 1003124

Test Code
MDFCPCD13S319 or 1003124

Alias/See Also
13q-; D13S319/ LAMP1

CPT Codes
88271x2, 88275

Instructions
Bone Marrow aspirate in a green top sodium heparin tube (2-3 mL) or Peripheral Blood in a green top sodium heparin tube (2-10 mL).

Transport Container
Blood or Bone Marrow: Do not centrifuge.

Transport Temperature
Blood or Bone Marrow: Ambient temperature within 24 hours. Specimen can be refrigerated if not transported immediately. Do not freeze. Protect from heat with a cold pack.

Specimen Stability
Blood and Bone Marrow: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable

Methodology
Fluorescence in situ hybridization (FISH)

Setup Schedule
Monday - Friday

Report Available
Up to 7 days

Limitations
Laboratory test results should always be considered in the context of clinical observations. This test was developed and its performance characteristics determined by med fusion. It has not been cleared or approved by the U.S. Food and Drug Administration
(FDA). The FDA has determined that such clearance or approval is not necessary. This test is used for clinical purposes. It should not be regarded as investigational for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments
of 1988 (CLIA) as qualified to perform high complexity clinical laboratory testing.

Reference Range
An interpretive report will be provided.

Clinical Significance
Deletion of 13q (D13S319) is found in approximately 20% of multiple myeloma (MM) patients by classical karyotyping and in about 50% of MM patients by fluorescence in situ hybridization (FISH). It is also seen in MGUS, suggesting that it is an early event in the development of MM. Monosomy 13 or deletion (13q) identified by classical cytogenetic analysis is a strong adverse prognostic factor in MM patients treated with standard chemotherapy or high-dose chemotherapy and hematopoietic stem cell transplantation.

Performing Laboratory
med fusion



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.