D13S319 (13q13.4) deletion by FISH : 1003124

MDFCPCD13S319 or 1003124

13q-; D13S319/ LAMP1

Bone Marrow aspirate in a green top sodium heparin tube (2-3 mL) or Peripheral Blood in a green top sodium heparin tube (2-10 mL).

Blood or Bone Marrow: Do not centrifuge.

Blood or Bone Marrow: Ambient temperature within 24 hours. Specimen can be refrigerated if not transported immediately. Do not freeze. Protect from heat with a cold pack.

Blood and Bone Marrow: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable

Monday - Friday

Up to 7 days

Laboratory test results should always be considered in the context of clinical observations. This test was developed and its performance characteristics determined by med fusion. It has not been cleared or approved by the U.S. Food and Drug Administration
(FDA). The FDA has determined that such clearance or approval is not necessary. This test is used for clinical purposes. It should not be regarded as investigational for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments
of 1988 (CLIA) as qualified to perform high complexity clinical laboratory testing.

An interpretive report will be provided.

Deletion of 13q (D13S319) is found in approximately 20% of multiple myeloma (MM) patients by classical karyotyping and in about 50% of MM patients by fluorescence in situ hybridization (FISH). It is also seen in MGUS, suggesting that it is an early event in the development of MM. Monosomy 13 or deletion (13q) identified by classical cytogenetic analysis is a strong adverse prognostic factor in MM patients treated with standard chemotherapy or high-dose chemotherapy and hematopoietic stem cell transplantation.