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Histone Antibodies : 37056

Test Code
HISTOQ or 37056


CPT Codes
83516

Preferred Specimen
1 mL serum


Minimum Volume
0.3 mL


Instructions
Overnight fasting is preferred


Transport Temperature
Refrigerated


Specimen Stability
Ambient: 24 hours
Refrigerated: 14 days
Frozen: 30 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis; grossly lipemic; heat-treated, or specimens containing heavy, visible particulate


Methodology
Enzyme Immunoassay (EIA)

Setup Schedule
Tuesday & Thursday & Saturday


Report Available
2-5 days (From receipt at performing laboratory)


Reference Range
less than  0 U                    Negative
1.0-1.5 U                          Weak Positive
1.6-2.5 U                          Moderate Positive
greater than 2.5 U             Strong Positive


Clinical Significance
Histone antibody is present in 80-95% of patients with drug-induced Systemic Lupus Erythematosus (SLE), 20-50% of patients with idiopathic SLE, and infrequently in patients with other autoimmune connective tissue diseases.


Performing Laboratory
Quest Diagnostics



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.