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Coenzyme Q10 : 19826
Test CodeCOQ10 or 19826
CPT Codes
82542
Instructions
Fasting is not required. Patients should not take Coenzyme Q10 supplements the morning of the test. They may take other nutritional supplements prior to testing.
Serum separator tube. Protect from light.
Serum separator tube. Protect from light.
Transport Container
Protect from light during collection, storage, and shipment. Centrifuge serum separator ASAP and transfer 1 mL serum to an amber transport tube (preferred) or protect the transport tube from light with foil or place in an amber bag. (Min: 0.3 mL). Ship as soon as possible.
Transport Temperature
Refrigerated
Specimen Stability
After separation from cells: Ambient: Unacceptable; Refrigerated: 14 days; Frozen: 6 weeks
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Specimen without protection from light exposure.
Methodology
Liquid Chromatography/Tandem Mass Spectrometry
Setup Schedule
Monday - Friday
Report Available
3-5 days (From receipt at performing laboratory)
Reference Range
Effective 4-13-2020:
>0.35 ug/mL (Optimal relative risk: >0.35; High relative risk: <0.36)
>0.35 ug/mL (Optimal relative risk: >0.35; High relative risk: <0.36)
Clinical Significance
Coenzyme Q10 (CoQ10) is a fat soluble cofacter that is essential for energy producing metabolic pathways and for the proper functioning of the mitochondrial oxidative system. With insufficient CoQ10, the electron transfer activity of the mitochondria decreases, resulting in a net failure to produce the energy necessary to run the cell. Tissues with high energy demand have even greater demands for CoQ10. For example, heart muscle, which continually exerts a pumping action for an entire lifetime, has an immense need for the cofactor. Studies demonstrate the effectiveness of supplemental coenzyme Q10 in cardiomyopathy, myocardial dysfunction, and congestive heart failure. CoQ10 is also a powerful antioxidant like vitamins E and C, and thus serves the role of neutralizing excess free radicals. It is now well established that the control of excessive free radical activity is key in preventing/delaying the progression of degenerative diseases.
Performing Laboratory
Quest Diagnostics