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Aldosterone, LC/MS/MS : 17181
Test CodeALDOSQ or 17181
CPT Codes
82088
Instructions
Draw "upright" samples at least 1/2 hours after patient sits up.
Plain red top tube, sodium heparin (no-gel) green top tube, or lavender (EDTA) tube.
Plain red top tube, sodium heparin (no-gel) green top tube, or lavender (EDTA) tube.
Transport Container
Centrifuge plain red, sodium heparin, or EDTA tube and transfer 1 mL serum or plasma (Min: 0.25 mL) into a standard transport tube.
Transport Temperature
Refrigerated.
Specimen Stability
Ambient: 4 days; Refrigerated: 7 days; Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Samples collected in SST tubes, moderate to gross hemolysis
Methodology
Chromatography/Mass Spectrometry
Setup Schedule
Monday - Saturday
Report Available
3-5 days (From receipt at performing laboratory)
Limitations
Aldosterone concentration varies based on body position and sodium intake. 24-hour urine specimens for aldosterone are an alternative.
Reference Range
Adult
Upright 8:00-10:00 A.M. less than or equal to 28 ng/dL
Upright 4:00-6:00 P.M. less than or equal to 21 ng/dL
Supine 8:00-10:00 A.M. 3-16 ng/dL
Pediatric
1-12 Months 2-70 ng/dL
1-4 Years 2-37 ng/dL
5-9 Years less than or equal to 9 ng/dL
10-13 Years less than or equal to 21 ng/dL
14-17 Years less than or equal to 35 ng/dL
Infants
Premature (31-35 Weeks) less than or equal to 144 ng/dL
Term less than or equal to 217 ng/dL
Tanner Stages
II-III Males 1-13 ng/dL
II-III Females 2-20 ng/dL
IV-V Males 3-14 ng/dL
IV-V Females 4-32 ng/dL
Upright 8:00-10:00 A.M. less than or equal to 28 ng/dL
Upright 4:00-6:00 P.M. less than or equal to 21 ng/dL
Supine 8:00-10:00 A.M. 3-16 ng/dL
Pediatric
1-12 Months 2-70 ng/dL
1-4 Years 2-37 ng/dL
5-9 Years less than or equal to 9 ng/dL
10-13 Years less than or equal to 21 ng/dL
14-17 Years less than or equal to 35 ng/dL
Infants
Premature (31-35 Weeks) less than or equal to 144 ng/dL
Term less than or equal to 217 ng/dL
Tanner Stages
II-III Males 1-13 ng/dL
II-III Females 2-20 ng/dL
IV-V Males 3-14 ng/dL
IV-V Females 4-32 ng/dL
Clinical Significance
Approximately 1-2% of individuals with primary hypertension have primary hyperaldosteronism characterized by hypokalemia (low potassium) and low direct renin. Because serum aldosterone concentrations vary due to dietary sodium intake and body position, some physicians prefer measurement of 24-hour urine concentration for aldosterone.
Performing Laboratory
Quest Diagnostics
