Catecholamines, Fractionated, Random Urine : 5244

Test Code

UCATRN or 5244

Alias/See Also

Noradrenaline, Urine; Epinephrine, Urine; Dopamne, Urine

CPT Codes
82384, 82570

Includes

Includes: Creatinine, Norepinephrine, Epinephrine, Dopamine, and Total Catecholamines (calculated)

Instructions

It is preferable for the patient to be off medications for three days prior to collection. However, common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) cause minimal or no interference. Patient should avoid alcohol, coffee, tea, tobacco and strenuous exercise prior to collection.

Collect random urine.

Transport Container

Transfer a 10 mL aliquot from a well-mixed random collection to a transport container. (Min: 5 mL) Urine with a pH of 6 or less can be transported without preservatives if transported within 24 hours of the completion of collection. If longer than 24 hours, adjust the pH of the Urine with 6 N HCl to pH <3 OR send unpreserved urine frozen.

Transport Temperature

Refrigerated or Frozen.

Specimen Stability

Preserved: Ambient: 7 days; Refrigerated: 7 days; Frozen: 28 days
Unpreserved: Ambient: Unacceptable; Refrigerated: 7 days; Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

pH >3.0 and received unfrozen

Methodology
Ultra Performance Liquid Chromatography, Electrochemical

Setup Schedule

Monday - Friday

Report Available

3-6 days (From receipt at performing laboratory)

Limitations

Recent surgery, traumatic injury, upright posture, cold, anxiety, pain, clonidine withdrawal, and concurrent acute or chronic illness may produce elevated results.

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range

Epinephrine:
Age   mcg/g creatinine
Birth-6 Months 2-45
7-11 Months 5-45
1-2 Years 1-49
3-8 Years 4-32
9-12 Years 1-15
13-17 Years 1-10
Adults 2-16

Norepinephrine:
Age         mcg/g creatinine
Birth-6 Months 12-286
7-11 Months 19-250
1-2 Years 25-210
3-8 Years 20-108
9-12 Years 20-73
13-17 Years 15-58
Adults 7-65

Total N + NE:
Age           mcg/g creatinine
Birth-6 Months 24-322
7-11 Months 10-295
1-2 Years 30-263
3-8 Years 30-130
9-12 Years 25-90
13-17 Years 20-70
Adults 9-74

Dopamine:
Age       mcg/g creatinine
Birth-6 Months 107-2180
7-11 Months 96-2441
1-2 Years 86-1861
3-8 Years 295-1123
9-12 Years 164-744
13-17 Years 156-551
Adults 40-390

Creatinine, Random Urine
less than or equal to 6 Months    2-28 mg/dL
7-11 Months     2-31 mg/dL
1-2 Years            2-110 mg/dL
3-8 Years            2-130 mg/dL
9-12 Years          2-160 mg/dL
greater than 12 Years
   Male       20-320 mg/dL
   Female   20-275 mg/dL

Clinical Significance

The three catecholamines (norepinephrine, epinephrine, and dopamine) are the principal secretory products of neural tissue. Clinically, the measurement of circulating catecholamines is valuable in the diagnosis of catecholamine secreting tumors associated chiefly with hypertension (pheochromocytomas, neuroblastomas, and gangliomas) and with the evaluation of orthostatic hypotension.

Performing Laboratory
Quest Diagnostics

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.