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Insulin Autoantibody : 36178
Test CodeINSABQ or 36178
CPT Codes
86337
Instructions
Serum separator tube or plain red.
Transport Container
Centrifuge the serum separator tube and transport. If plain red, centrifuge and aliquot 1 mL serum (Min: 0.2 mL) into a standard transport tube.
Transport Temperature
Refrigerated.
Specimen Stability
Ambient: 28 days; Refrigerated: 28 days; Frozen: 28 days
Methodology
Radiobinding Assay (RBA)
Setup Schedule
Sunday & Tuesday & Thursday
Report Available
4-7 days (From receipt at performing laboratory)
Limitations
In diabetic children <14 years of age (identified by urine screening), the frequency of insulin antibodies (IAA) and islet cell antibodies (ICA) are 43-56% and 84%, respectively; the frequency of both is 40%, and the frequency of one or both is 88%.4 In the same study, cohorts using ICA, GAD-65 antibodies and IAA, sensitivities and specificities are 93% and 93% for any positive, respectively, and 39% and >99%, respectively, for all positives. IAA are found at onset of diabetes in only 4% of adults, but are universally present in diabetic children <4 years old at onset. The predictive value of both tests (ICA and IAA) is 60-77% in first-degree relatives of patients with IDDM for the development of IDDM in 5-10 years.
Reference Range
less than 0.4 U/mL
Clinical Significance
Type 1 diabetes is characterized by lymphocytic cell
infiltrate of the pancreatic islets. Insulin Antibody is
useful in assessing lower titers of autoantibody in
patients with diabetes, detecting insulin autoantibody in
patients who are ''prediabetic,'' and in detecting
autoantibody in patients with other autoimmune disorders.
Measurement of GAD-65, ICA-512, and Insulin Antibody is a
highly sensitive means to assess risk and predict onset of
Type I diabetes. There is a correlation between the number
of positive antibodies and the antibody titers versus the
severity of the autoimmune process.
infiltrate of the pancreatic islets. Insulin Antibody is
useful in assessing lower titers of autoantibody in
patients with diabetes, detecting insulin autoantibody in
patients who are ''prediabetic,'' and in detecting
autoantibody in patients with other autoimmune disorders.
Measurement of GAD-65, ICA-512, and Insulin Antibody is a
highly sensitive means to assess risk and predict onset of
Type I diabetes. There is a correlation between the number
of positive antibodies and the antibody titers versus the
severity of the autoimmune process.
Performing Laboratory
Quest Diagnostics
