MPN Mini Profile : 1016704

Test Code

Alias/See Also
Myeloproliferative neoplasms; MPN; CALR; JAK2; MPL

CPT Codes
81219, 81270, 81338, 81279

Includes: JAK2 (V617F, Exon 12, Exon 13, Exon 14), MPL, CALR

Peripheral Blood  in a lavender top (EDTA) tube and/or a green top sodium heparin tube.


Bone Marrow in a lavender top (EDTA) tube and/or a green top sodium heparin tube.

Transport Container
Submit 5-10 mL Blood in a lavender top and/or 5-10 mL Blood in a green top.
Submit 2-3 mL Bone Marrow in a lavender top and/or 2-3 mL Bone Marrow in a green top.

Do not centrifuge.

Transport Temperature

Specimen Stability
Ambient: 48 hours; Refrigerated: 15 days; Frozen: Unacceptable

Next Generation Sequencing

Setup Schedule
Monday & Thursday

Report Available
8-10 days

Reference Range
Mutation not detected.

Clinical Significance
The MPN mini profile detects disease-defining, potentially targetable mutations in JAK2, CALR, and MPL for myeloproliferative neoplasms. These 3 genes are growth-promoting oncogenes that operate through a signaling pathway mediated by JAK2, and MPNs with these mutations can respond to clinically available JAK2 inhibitors. The inclusion of hot spot mutation testing in these 3 genes into the routine workup of MPNs is recommended by the World Health Organization’s classifications of hemtalogical malignancies and the National Comprehensive Cancer Network (NCCN) guidelines. This combined testing method provides diagnostic assistance, provides a clonal molecular marker of disease following diagnosis and post therapy follow-up, influences prognosis, and identifies those MPNs that may potentially benefit from JAK2 inhibitor therapy.

Performing Laboratory
med fusion

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.