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Bladder Cancer, FISH : 10107
Test CodeUROVYS or 10107
Alias/See Also
CEP 3, CEP 7, CEP 17, LSI 9p21 (p16) , Monitoring, Uro-Vision, Uro-Vysion, UroVysion (TM) Multicolor Probe, Urovision, Bladder Cancer Recurrence, hematuria
CPT Codes
88120
Instructions
Preferred Specimen: 50 mL urine (33 mL minimum) voided urine mixed 2:1 with PreservCyt®. Transfer 50 mL to tightly capped plastic container
Alternative Specimen: Bladder washing in a steile leak-proof container.
A urine preservative transport kit, with handling instructions, is available upon request from client supplies order code K141 or contact client services.
Alternative Specimen: Bladder washing in a steile leak-proof container.
A urine preservative transport kit, with handling instructions, is available upon request from client supplies order code K141 or contact client services.
Transport Container
Urine (preferred): Perform urine collection (50 mL) at the physician's office in a sterile 100 mL urine specimen container. Mix voided urine with CytoLyt® or ethanol 50% in a 1:1 solution. Alternatively, mix urine with preservative Carbowax™ (2% polyethylene glycol in 50% ethanol) 2:1 (v:v).
Bladder washings (acceptable): Perform bladder washing collection (50 mL) at the physician's office in a sterile 100 mL urine specimen container. Mix bladder washing with CytoLyt® or ethanol 50% in a 1:1 solution. Alternatively, mix bladder washing with preservative Carbowax™ (2% polyethylene glycol in 50% ethanol) 2:1 (v:v).
It is recommended that specimens be processed within 72 hours of collection. Samples received without preservative will be assayed; any study under these conditions yielding insufficient cells or an abnormal result should have a follow-up study with urine in a preservative. Cold packs are recommended during transportation. If bladder washing is not shipped immediately after collection, refrigerate immediately (do not freeze). Under no circumstances should bladder washing specimens be stored or shipped at temperatures at or above 37° C.
Bladder washings (acceptable): Perform bladder washing collection (50 mL) at the physician's office in a sterile 100 mL urine specimen container. Mix bladder washing with CytoLyt® or ethanol 50% in a 1:1 solution. Alternatively, mix bladder washing with preservative Carbowax™ (2% polyethylene glycol in 50% ethanol) 2:1 (v:v).
It is recommended that specimens be processed within 72 hours of collection. Samples received without preservative will be assayed; any study under these conditions yielding insufficient cells or an abnormal result should have a follow-up study with urine in a preservative. Cold packs are recommended during transportation. If bladder washing is not shipped immediately after collection, refrigerate immediately (do not freeze). Under no circumstances should bladder washing specimens be stored or shipped at temperatures at or above 37° C.
Transport Temperature
Refrigerated.
Specimen Stability
Ambient: See collection instructions; Refrigerated: See collection instructions; Frozen: See colection instructions
Specimen viability decreases during transit.
Specimen viability decreases during transit.
Methodology
- Fluorescence in situ Hybridization
Setup Schedule
Sunday - Saturday
Report Available
4 days (From receipt at performing laboratory)
Reference Range
See Laboratory Report
Clinical Significance
UroVysion® FISH, detects aneuploidy of chromosomes 3,7,17 and loss of 9p21 locus. Useful for monitoring bladder cancer and in the initial diagnosis of bladder cancer in patients with hematuria.
Performing Laboratory
Quest Diagnostics
