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Bladder Cancer, FISH : 10107
Test CodeUROVYS or 10107
Alias/See Also
CEP 3, CEP 7, CEP 17, LSI 9p21 (p16) , Monitoring, Uro-Vision, Uro-Vysion, UroVysion (TM) Multicolor Probe, Urovision, Bladder Cancer Recurrence, hematuria
CPT Codes
88120
Preferred Specimen
50 mL voided urine collected in PreservCyt®, CytoLyt®, or ethanol 50%
Minimum Volume
33 mL
Other Acceptable Specimens
Bladder washing collected in a sterile leak-proof PreservCyt, CytoLyt, or ethanol 50%
Instructions
Urine (preferred): A urine preservative transport kit, with handling instructions, is available upon request. Perform urine collection (50 mL) at the physician's office or Patient Service Center (PSC) in a sterile 100 mL urine specimen container. Mix voided urine with PreservCyt, CytoLyt, or ethanol 50% in a 1:1 solution. Alternatively, mix urine with preservative Carbowax™ (2% polyethylene glycol in 50% ethanol) 2:1 (v:v).
Bladder washings (acceptable): Perform bladder washing collection (50 mL) at the physician's office in a sterile 100 mL urine specimen container. Mix bladder washing with PreservCyt, CytoLyt, or ethanol 50% in a 1:1 solution. Alternatively, mix bladder washing with preservative Carbowax (2% polyethylene glycol in 50% ethanol) 2:1(v:v).
It is recommended that specimens be processed within 72 hours of collection. Samples received without preservative will be assayed; any study under these conditions yielding insufficient cells or an abnormal result should have a followup study with urine in a preservative. Cold packs are recommended during transportation. If bladder washing is not shipped immediately after collection, refrigerate immediately (Do Not Freeze). Under no circumstances should bladderwashing specimens be stored or shipped at temperatures at or above 37 degrees Celsius.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do Not Freeze. **Do Not Reject**
Bladder washings (acceptable): Perform bladder washing collection (50 mL) at the physician's office in a sterile 100 mL urine specimen container. Mix bladder washing with PreservCyt, CytoLyt, or ethanol 50% in a 1:1 solution. Alternatively, mix bladder washing with preservative Carbowax (2% polyethylene glycol in 50% ethanol) 2:1(v:v).
It is recommended that specimens be processed within 72 hours of collection. Samples received without preservative will be assayed; any study under these conditions yielding insufficient cells or an abnormal result should have a followup study with urine in a preservative. Cold packs are recommended during transportation. If bladder washing is not shipped immediately after collection, refrigerate immediately (Do Not Freeze). Under no circumstances should bladderwashing specimens be stored or shipped at temperatures at or above 37 degrees Celsius.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do Not Freeze. **Do Not Reject**
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: See instructions
Refrigerated: See instructions
Frozen: Unacceptable
Specimen viability decreases during transit.
Refrigerated: See instructions
Frozen: Unacceptable
Specimen viability decreases during transit.
Methodology
Fluorescence in situ Hybridization (FISH)
Setup Schedule
Daily
Report Available
4 days (From receipt at performing laboratory)
Limitations
The analytical performance characteristics of this assay have been determined by Quest Diagnostics. The modifications have not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Reference Range
See Laboratory Report
Clinical Significance
UroVysion® FISH, detects aneuploidy of chromosomes 3,7,17 and loss of 9p21 locus. Useful for monitoring bladder cancer and in the initial diagnosis of bladder cancer in patients with hematuria.
Performing Laboratory
Quest Diagnostics
