1p/19q deletion by FISH : 1001039

Please provide most recent Pathology report.

MDFCP1P19QFNB or 1001039

1p-/19q in Glioma; 1p/19q Deletion Detection; FISH for 1p/19q Deletion in Gliomas ; LOH (Loss of Heterozygosity) 1p/19q in Gliomas; Loss of Heterozygosity (LOH) 1p/19q in Gliomas; Oligodendroglioma

Tissue.

Paraffin embedded formalin fixed tissue that has been fixed in 10% neutral buffered formalin for at least 6 hours and no longer than 48 hours. Four unstained slides, with tissue of 4 microns in thickness are needed for processing, accompanied by a circled H & E clearly indicating the area to be examined.

Paraffin embedded tissue block: Ambient or on ice pack in summer. Slides: Ambient.

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Monday - Friday

Up to 7 days

Laboratory test results should always be considered in the context of clinical observations.. This test was developed and its performance characteristics determined by med fusion. It has not been cleared or approved by the U.S. Food and Drug Administration
(FDA). The FDA has determined that such clearance or approval is not necessary. This test is used for clinical purposes. It should not be regarded as investigational for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments
of 1988 (CLIA) as qualified to perform high complexity clinical laboratory testing.

An interpretive report will be provided.

Anaplastic oligodendrogliomas are characterized by a unique compilation of molecular genetic changes, including coincident loss of chromosomal arms 1p and 19q in 50%-70% of tumors. Allelic loss (or loss of heterozygosity) of chromosome 1p is a statistically significant predictor of chemosensitivity, and combined loss involving chromosomes 1p and 19q is statistically significantly associated with both chemosensitivity and longer recurrence-free survival after chemotherapy.