Plasminogen Activity : 4458

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Test Code
PLASMA or 4458

CPT Codes

Lt. blue (sodium citrate). Fill light blue-top tubes as far as vacuum will allow and mix by gentle inversion 3-4 times.

Transport Container
Centrifuge light blue-top tube 15 minutes at approx. 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into standard plastic transport tube.  Freeze immediately 1 mL plasma (Min. 0.5 mL).

Transport Temperature

Specimen Stability
Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross Hemolysis,  Grossly Lipemic, Grossly Icteric

Chromogenic Substrate

Setup Schedule
Monday & Wednesday & Friday

Report Available
1-3 days (From receipt at performing laboratory)

Reference Range

Clinical Significance
The precursor of plasmin is plasminogen, plasmin lyses fibrin clots. Activity is increased in pregnancy and as an acute phase reactant. Rare hereditary deficiency of plasminogen predisposes to venous thrombosis. Low activity is associated with DIC, liver disease, and increased risk of thrombosis.

Performing Laboratory
Quest Diagnostics

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.