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JC Polyoma Virus DNA, Qualitative, PCR, CSF : 16441
Test CodeJCVPCR or 16441
Alias/See Also
JC Virus
CPT Codes
87798
Instructions
CSF (cerebrospinal fluid).
Transport Container
Submit 0.7 mL CSF (Min. 0.3 mL) in a sterile plastic screw capped tube.
Transport Temperature
Refrigerated.
Specimen Stability
CSF: Ambient: 48 hours; Refrigerated: 7 days; Frozen: 30 days
Methodology
Real-Time Polymerase Chain Reaction (RT-PCR)
Setup Schedule
Monday - Saturday
Report Available
1-3 days (From receipt at performing laboratory)
Limitations
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Reference Range
Not detected
Clinical Significance
JC Polyoma Virus (JCV) is the cause of progressive multifocal leukoencephalopathy (PML), a demyelinating neurologic disease of immunosuppressed patients. This test detects JC Polyoma Virus DNA in CSF. Detection of the virus in specimens from AIDS and other severely immune compromised patients may indicate disease. Serum antibodies are not helpful in diagnosing PML as antibodies are common in the general population. JCV can also be detected in the urine of 3% of pregnant women, but is not associated with proven disease.
Performing Laboratory
Quest Diagnostics
