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Plasminogen Activator Inhibitor-1 (PAI-1) 4G/5G : 11368
Test CodePAI1Q or 11368
Alias/See Also
PAI-1 Promoter Polymorphism, PAI-4G/5G Polymorphism, Plasminogen Activator Inhibitor-1 4G/5G Polymorphism, Quest-Plasminogen Activator Inhibitor-1 4G/5G Polymorphism
CPT Codes
81400
Instructions
Lavender (EDTA), green (no gel) (sodium heparin), yellow (ACD Solution A or B), or royal blue (EDTA).
Transport Container
Transport 5 mL whole blood, (Min: 3 mL).
Transport Temperature
Refrigerated.
Specimen Stability
Ambient: 8 days; Refrigerated: 8 days; Frozen: Unacceptable
Methodology
Polymerase Chain Reaction and Detection
Setup Schedule
Wednesday & Saturday
Report Available
6-10 days (From receipt at performing laboratory)
Limitations
This test was developed and its performance characteristics have been determined by Quest Diagnostics. Performance characteristics refer to the analytical performance of the test.
Reference Range
See Laboratory Report.
Clinical Significance
Plasma plasminogen activator inhibitor, PAI-1 is a major inhibitor of fibrinolysis. The 4G variant (AF386492.2:g.837del) in the PAI-1 (Serpine 1) gene promoter region is associated with an increase in the level of PAI-1 in plasma. Increased levels of PAI-1 in plasma may increase the risk for arterial and venous thrombosis, myocardial infarction, and progression of atherosclerosis and also recurrent spontaneous abortion.
Performing Laboratory
Quest Diagnostics
