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Nicotine and Cotinine, Urine : 90646
Test CodeUNICOT or 90646
CPT Codes
80323 (HCPCS: G0480)
Instructions
Random urine.
Transport Container
Transport 1 mL urine with no additives or preservatives. (Min: 0.5 mL) Submit specimen in transport tube.
Transport Temperature
Refrigerated.
Specimen Stability
Ambient: 72 hours; Refrigerated: 21 days; Frozen: 30 days
Methodology
Liquid Chromatography/Mass Spectrometry
Setup Schedule
Monday & Wednesday & Friday
Report Available
4 days (From receipt at performing laboratory)
Limitations
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Reference Range
Nicotine
Smokers 200-700 ng/mL
Nonsmokers less than or equal to 7 ng/mL
Cotinine
Smokers 300-1300 ng/mL
Nonsmokers less than or equal to 20 ng/mL
Smokers 200-700 ng/mL
Nonsmokers less than or equal to 7 ng/mL
Cotinine
Smokers 300-1300 ng/mL
Nonsmokers less than or equal to 20 ng/mL
Clinical Significance
This assay is used for the detection of nicotine and cotinine in urine to determine the tobacco exposure status of the individual. Nicotine has a short half-life of approximately forty minutes; Its presence may indicate recent tobacco exposure. Cotinine, the major nicotine metabolite, has a half-life of 24 hours and is detectable for several days after cessation of tobacco exposure.
Performing Laboratory
Quest Diagnostics