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Nicotine and Cotinine, Serum/Plasma : 90642
Test CodeNICOT or 90642
CPT Codes
80323
Instructions
Plain red or lavender (EDTA).
Transport Container
Centrifuge plain red or lavender top and aliquot 1 mL serum or plasma (Min: 0.5 mL) into a standard transport tube. Also acceptable: transport EDTA whole blood.
Transport Temperature
Refrigerated.
Specimen Stability
After separation from cells: Ambient: 72 hours; Refrigerated: 21 days; Frozen: 30 days
Whole blood: Ambient: 72 hours; Refrigerated: 21 days; Frozen: Unacceptable
Whole blood: Ambient: 72 hours; Refrigerated: 21 days; Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis; Serum Separator tube
Methodology
Liquid Chromatography/Mass Spectrometry
Setup Schedule
Monday & Wednesday & Friday
Report Available
4 days (From receipt at performing laboratory)
Reference Range
Nicotine
Smokers 2-10 ng/mL
Nonsmokers less than or equal to 4 ng/mL
Cotinine
Smokers 16-145 ng/mL
Nonsmokers less than or equal to 8 ng/mL
Smokers 2-10 ng/mL
Nonsmokers less than or equal to 4 ng/mL
Cotinine
Smokers 16-145 ng/mL
Nonsmokers less than or equal to 8 ng/mL
Clinical Significance
This assay is used for the detection of nicotine and cotinine in serum and plasma to determine the tobacco exposure status of the individual. Nicotine has a short half-life of approximately forty minutes; Its presence may indicate recent tobacco exposure. Cotinine, the major nicotine metabolite, has a half-life of 24 hours and is detectable for several days after cessation of tobacco exposure.
Performing Laboratory
Quest Diagnostics
