MDS Panel by FISH : 1001100

Test Code
MDFCPCMDSP or 1001100

Alias/See Also
myelodysplastic syndrome panel

CPT Codes
88271x6, 88275x3

Includes
Panel includes: Monosomy 5/deletion 5q; Monosomy 7/deletion 7q; Trisomy 8; D20S108 (20q12).

Instructions
Bone Marrow aspirate in a green top sodium heparin tube (2-3 mL) or Peripheral Blood in a green top sodium heparin tube (2-10 mL).

Transport Container
Blood or Bone Marrow: Do not centrifuge.

Transport Temperature
Blood or Bone Marrow: Ambient temperature within 24 hours. Specimen can be refrigerated if not transported immediately. Do not freeze. Protect from heat with a cold pack.

Specimen Stability
Blood and Bone Marrow: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable

Methodology
Fluorescence in situ hybridization (FISH)

Setup Schedule
Monday - Friday

Report Available
Up to 7 days

Limitations
Laboratory test results should always be considered in the context of clinical observations. This test was developed and its performance characteristics determined by med fusion. It has not been cleared or approved by the U.S. Food and Drug Administration
(FDA). The FDA has determined that such clearance or approval is not necessary. This test is used for clinical purposes. It should not be regarded as investigational for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments
of 1988 (CLIA) as qualified to perform high complexity clinical laboratory testing.

Reference Range
An interpretive report will be provided.

Clinical Significance
MDS is hematologic disorder characterized by heterogeneity in morphological and clinical presentation and approximately 50% of the cases have chromosome abnormalities. Cytogenetic studies have a major role in the evaluation of patients with MDS in regard to prognosis, clonality assessment and the recognition of cytogenetic, morphologic and clinical correlates. FISH can detect the abnormalities as deletions of chromosomes 5q, 7q, 20q and Trisomy 8 with a better sensitivity than classical chromosome analysis by karyotyping.

Performing Laboratory
med fusion



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.