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5-Hydroxyindoleacetic Acid (5-HIAA), Random Urine with Creatinine : 1648
Test CodeU5HIRQ or 1648
Alias/See Also
5-Hydroxyindoleacetic Acid , Serotonin Metabolite
CPT Codes
83497, 82570
Includes
Includes Creatinine.
Instructions
Patient should avoid food high in indoles: avocado, banana, tomato, plum, walnut, pineapple, and eggplant.
Collect random urine. Refrigerate immediately after collection.
Collect random urine. Refrigerate immediately after collection.
Transport Container
Transport 10 mL urine aliquot, (Min: 5 mL). Keep refrigerated.
If transported to laboratory within 24 hours after collection, transport refrigerated.
If transport is delayed, see below alternate processing/transportation instructions:
A. After urine collection, add 6N HCl to maintain a pH below 3. Transport 10 mL aliquot of pH adjusted (less than pH 3) urine, refrigerated.
OR
B. If 6N HCL is not available, freeze 10 mL aliquot of urine and transport frozen.
If transported to laboratory within 24 hours after collection, transport refrigerated.
If transport is delayed, see below alternate processing/transportation instructions:
A. After urine collection, add 6N HCl to maintain a pH below 3. Transport 10 mL aliquot of pH adjusted (less than pH 3) urine, refrigerated.
OR
B. If 6N HCL is not available, freeze 10 mL aliquot of urine and transport frozen.
Transport Temperature
Refrigerated.
Specimen Stability
Refrigerate immediately after collection. Transport ASAP.
After preservation with 6 N HCL to pH 3: Ambient: 7 days; Refrigerated: 30 days; Frozen: 30 days
After preservation with 6 N HCL to pH 3: Ambient: 7 days; Refrigerated: 30 days; Frozen: 30 days
Methodology
High Performance Liquid Chromatography, Electrochemical Detection
Setup Schedule
Tuesday & Thursday & Friday
Report Available
3-7 days (From receipt at performing laboratory)
Limitations
Patients with renal disease may display falsely decreased results. Urinary 5-HIAA is increased in patients with malabsorption disorders who also display a larger concentration of urinary tryptophan metabolites. Urinary 5-HIAA is increased in patients with intestinal obstruction and with some noncarcinoid islet cell tumors. Carcinoid syndrome may not cause elevated results, especially if the patient does not have diarrhea.
Reference Range
2-10 years: less than or equal to 12.0 mg/g creat
>10 years: less than or equal to 10.0 mg/g creat
Reference Ranges for Creatinine, Random Urine
< = or 6 Months 2-28 mg/dL
7-11 Months 2-31 mg/dL
1-2 Years 2-110 mg/dL
3-8 Years 2-130 mg/dL
9-12 Years 2-160 mg/dL
>12 Years Male 20-320 mg/dL
>12 Years Female 20-275 mg/dL
>10 years: less than or equal to 10.0 mg/g creat
Reference Ranges for Creatinine, Random Urine
< = or 6 Months 2-28 mg/dL
7-11 Months 2-31 mg/dL
1-2 Years 2-110 mg/dL
3-8 Years 2-130 mg/dL
9-12 Years 2-160 mg/dL
>12 Years Male 20-320 mg/dL
>12 Years Female 20-275 mg/dL
Clinical Significance
Values above 10 mg/24 hrs occur in carcinoid syndrome. Slight elevations also occur in nontropical sprue and after reserpine administration.
Drugs which can interfere with testing due to physiologic response: Acetaminophen, Alpha and Beta Blockers, Atenolol, Bromocriptine, Bronchodilators, Clonidine, Digoxin, Isoniazid, L-Dopa, Labetelol, Methyldopa, Monoamine Oxidase Inhibitors, Nitroglycerin, Sympathomimetic Amines, Phenobarbital, Phenothiazines, Phentolamine, Reserprine, Salicylates, Tricyclic Antidepressants
Drugs which can interfere with testing due to physiologic response: Acetaminophen, Alpha and Beta Blockers, Atenolol, Bromocriptine, Bronchodilators, Clonidine, Digoxin, Isoniazid, L-Dopa, Labetelol, Methyldopa, Monoamine Oxidase Inhibitors, Nitroglycerin, Sympathomimetic Amines, Phenobarbital, Phenothiazines, Phentolamine, Reserprine, Salicylates, Tricyclic Antidepressants
Performing Laboratory
Quest Diagnostics
