5-HIAA (5-Hydroxyindoleacetic Acid), Random Urine : 1015171

Test Code
U5HIRQ or 1015171

Alias/See Also
Carcinoid Screen; 5-HIAA; 5HIAA

CPT Codes
83497, 82570

Includes
Includes Creatinine.

Instructions
Patient should avoid food high in indoles: avocado, banana, tomato, plum, walnut, pineapple, and eggplant.

Collect random urine. Refrigerate immediately after collection.

Transport Container
Transport 10 mL urine aliquot, (Min: 5 mL). Keep refrigerated.

If transported to laboratory within 24 hours after collection, transport refrigerated.

If transport is delayed, see below alternate processing/transportation instructions:
A. After urine collection, add 6N HCl to maintain a pH below 3. Transport 10 mL aliquot of pH adjusted (less than pH 3) urine, refrigerated.
OR
B. If 6N HCL is not available, freeze 10 mL aliquot of urine and transport frozen.


Transport Temperature
Refrigerated.

Specimen Stability
Refrigerate immediately after collection. Transport ASAP.

After preservation with 6 N HCL to pH 3: Ambient: 7 days; Refrigerated: 30 days; Frozen: 30 days

Methodology
High Performance Liquid Chromatography, Electrochemical Detection

Setup Schedule
Tuesday & Thursday & Friday

Report Available
3-7 days (From receipt at performing laboratory)

Limitations
Patients with renal disease may display falsely decreased results. Urinary 5-HIAA is increased in patients with malabsorption disorders who also display a larger concentration of urinary tryptophan metabolites. Urinary 5-HIAA is increased in patients with intestinal obstruction and with some noncarcinoid islet cell tumors. Carcinoid syndrome may not cause elevated results, especially if the patient does not have diarrhea.

Reference Range
2-10 years: less than or equal to 12.0 mg/g creat
>10 years: less than or equal to 10.0 mg/g creat

Clinical Significance
5-HIAA is the end product of serotonin (5-hydroxytryptophan) and tyrptophan metabolism. Patients with carcinoid tumors of the midgut, e.g., ileum, produce high concentrations of 5-HIAA. Patients with carcinoid tumors of the foregut and hindgut may produce little or no 5-HIAA or do so intermittently.

Performing Laboratory
Quest Diagnostics



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.