A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Porphobilinogen, Quantitative, Random Urine : 6329
Test CodeUPBGRN or 6329
Alias/See Also
PBG; Porphyria
CPT Codes
84110
Instructions
Random urine.
Preferred:
2 mL (1 mL minimum) urine (no preservative) collected in a plastic leak-proof container.
Acceptable:
Random clean catch urine collected with 0.5g sodium carbonate (Na2CO3) per 100 mL of sample.
Preferred:
2 mL (1 mL minimum) urine (no preservative) collected in a plastic leak-proof container.
Acceptable:
Random clean catch urine collected with 0.5g sodium carbonate (Na2CO3) per 100 mL of sample.
Transport Container
Urine should be refrigerated and protected from light.
Whenever possible, the specimen should be collected during an acute episode because porphobilinogen (PBG) may decrease rapidly upon remission. PBG may also degrade when samples are exposed to UV light for extended periods, or are transported at ambient temperature. If an amber collection jug/urine cup is not available, the sample must be protected from light by completely wrapping the container in aluminum foil. PBG is most stable at pH 6-7, but samples may be sent with or without preservative. All results should be interpreted in the context of clinical findings, relevant history, and other laboratory data.
Whenever possible, the specimen should be collected during an acute episode because porphobilinogen (PBG) may decrease rapidly upon remission. PBG may also degrade when samples are exposed to UV light for extended periods, or are transported at ambient temperature. If an amber collection jug/urine cup is not available, the sample must be protected from light by completely wrapping the container in aluminum foil. PBG is most stable at pH 6-7, but samples may be sent with or without preservative. All results should be interpreted in the context of clinical findings, relevant history, and other laboratory data.
Transport Temperature
Refrigerated.
Specimen Stability
Ambient: Unacceptable; Refrigerated: 7 days; Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Not protected from light.
Methodology
Chromatography/Mass Spectrometry
Setup Schedule
Tuesday & Thursday & Saturday
Report Available
3-6 days (From receipt at performing laboratory)
Reference Range
Pediatric <0.36 mg/g creat
Adult <0.22 mg/g creat
Adult <0.22 mg/g creat
Clinical Significance
Urinary Porphobilinogen is the first step in the diagnosis of acute intermittent porphyria (AIP). AIP is an autosomal dominant disorder characterized by deficiency of porphobilinogen deaminase. An acute attack usually includes gastrointestinal disturbance and neuropsychiatric disorders.
Performing Laboratory
Quest Diagnostics