A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
CLL Panel by FISH : 1001099
Test CodeMDFCPCCLLP or 1001099
Alias/See Also
chronic lymphocytic leukemia panel
CPT Codes
88271x11, 88275x5
Includes
Panel includes: MYB-6q23/ATM (11q23)/Trisomy 12/D13S319 (13q13.4)/IGH(14q32.3)/p53(17p13)/ IGH-CCNDD1 t(11;14) probes If IGH is positive, IGH-BCL2 t(14;18) probe will be performed at an additional charge (CPT code(s): 88271x2, 88275).
Instructions
Bone Marrow aspirate in a green top sodium heparin tube (2-3 mL) or Peripheral Blood in a green top sodium heparin tube (2-10 mL).
Transport Container
Blood or Bone Marrow: Do not centrifuge.
Transport Temperature
Blood or Bone Marrow: Ambient temperature within 24 hours. Specimen can be refrigerated if not transported immediately. Do not freeze. Protect from heat with a cold pack.
Specimen Stability
Blood and Bone Marrow: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable
Methodology
Fluorescence in situ hybridization (FISH)
Setup Schedule
Monday - Friday
Report Available
Up to 7 days
Limitations
Laboratory test results should always be considered in the context of clinical observations. This test was developed and its performance characteristics determined by med fusion. It has not been cleared or approved by the U.S. Food and Drug Administration
(FDA). The FDA has determined that such clearance or approval is not necessary. This test is used for clinical purposes. It should not be regarded as investigational for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments
of 1988 (CLIA) as qualified to perform high complexity clinical laboratory testing.
(FDA). The FDA has determined that such clearance or approval is not necessary. This test is used for clinical purposes. It should not be regarded as investigational for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments
of 1988 (CLIA) as qualified to perform high complexity clinical laboratory testing.
Reference Range
An interpretive report will be provided.
Clinical Significance
About 80% cases of CLL have cytogenetic abnormalities detected by FISH. About 50% of CLL show del 13q14.3, about 20% trisomy 12 and, less commonly deletions of 11q22, 17p13 and 6q21. Deletions of 17p and 6q are associated with a poor prognosis and isolated deletion of 13q14.3 is associated with a more favorable clinical outcome.
Performing Laboratory
med fusion