Multiple Myeloma Panel by Fish : 1001101

Test Code

MDFCPCMMP or 1001101

Alias/See Also

MM, Fluorescence in situ Hybridization, Multiple myeloma, Dyscrasia, Plasmacytoma, Plasma Cell Myeloma, PCM, MGUS, Plasma Cell Neoplasm

CPT Codes
88271x13, 88275x6

Includes

FISH probes targeting gain of 1q/loss of 1p; MYC (8q24); CEP 9,11,15; D13S319 (13q13.4); IGH (14q32); TP53 (17p13). Reflex: IGH-FGFR3, t(4;14); IGH-CCND1, t(11;14); IGH-MAF, t(14;16); IGH-MAFB, t(14;20).

If the result for IGH rearrangement is positive following initial FISH analysis, then the IGH reflex probes will be performed at an additional charge (CPT® codes(s): 88271 (x8), 88275 (x4)).

Instructions

3 mL bone marrow collected in a sodium heparin (green-top) tube
Minimum Volume: 1 mL

Transport Container

Preferred: Sodium heparin (green-top) tube
Alternative Specimen(s): Bone marrow collected in EDTA (lavender-top) tube

Transport Temperature

Room temperture
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. **Do not reject.**

Specimen Stability

Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable

Methodology
Fluorescence in situ hybridization (FISH)

Setup Schedule

Monday - Friday

Report Available

Up to 7 days

Limitations

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range

See Laboratory Report

Clinical Significance

Plasma cell myeloma is characterized by the proliferation of malignant monoclonal plasma cells in the bone marrow. This FISH panel is designed for clinical risk classification. Initial FISH testing is performed to detect deletion of TP53 (17p), rearrangements of IGH (14q32), rearrangements of MYC, gain of 1q, deletion of 1p, deletion of 13q/monosomy 13, and gain (trisomy) of chromosomes 9, 11, and 15 (for hyperdiploidy). When IGH rearrangement is positive, FISH for the specific IGH rearrangements, t(11;14), t(4;14), t(14;16), t(14;20), will be performed.

Performing Laboratory
med fusion

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.