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JAK2, Exon 12 Mutation Analysis : 92474
Test CodeJAK2 or 92474
Alias/See Also
Polycythemia Vera, ET, PMF, PV, Primary Myelofibrosis, Essential Thrombocythemia, Myeloproliferative neoplasm
CPT Codes
81279
Instructions
Lavender (EDTA) peripheral blood OR bone marrow (EDTA). Also acceptable: whole blood or bone marrow in Sodium heparin (green-top tube).
Transport Container
Do not freeze. Transport 4 mL whole blood (Min: 1 mL) OR 3 mL bone marrow (Min: 1 mL).
Transport Temperature
Refrigerated.
Specimen Stability
Ambient: 7 days; Refrigerated: 7 days; Frozen: Unacceptable
Methodology
Polymerase Chain Reaction- based DNA Sequencing
Setup Schedule
Sunday - Saturday
Report Available
5-7 days (From receipt at performing laboratory)
Limitations
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
This test is performed pursuant to a license agreement with Roche Molecular Systems, Inc.
This test is performed pursuant to a license agreement with Roche Molecular Systems, Inc.
Reference Range
Not detected
Clinical Significance
This DNA-based assay tests leukocytes from blood or bone marrow aspirate for mutations in exon 12 of JAK2, using an advanced DNA sequencing method. These mutations are associated with myeloproliferative neoplasms, particularly polycythemia vera.
Performing Laboratory
Quest Diagnostics
