AML Profile : 1016111

Test Code
MDFCPAMLPRO or 1016111


Alias/See Also
Acute Myeloid Leukemia; AML; Acute Promyelocytic Leukemia; APL; AML; ASXL1; c-KIT; DNMT3A; ETV6 (TEL); FLT3; IDH1; IDH2; KRAS; NPM1; NRAS; PHF6; PTEN; RUNX1; SF3B1; SRSF2; TET2; TP53; U2AF1; WT1; CEBPA; FLT3-ITD-TKD; MLL(11q23); RUNX1T1/RUNX1 t(8;21); PML/RARA t(15;17); CBFB (inversion 16); BCR/ABL t(9;22)


CPT Codes
81450, 88271x10, 88275x5

Includes
Includes: Molecular: ASXL1, CEBPA, DNMT3A, ETV6 (TEL), FLT3, FLT3-ITD, IDH1, IDH2, KIT, KRAS, NPM1, NRAS, PHF6, PTEN, RUNX1, SF3B1, SRSF2, TET2, TP53, U2AF1, WT1 Cytogentic: MLL (11q23) rearrangement, RUNX1T1(ETO)/RUNX1(AML1) t(8;21) translocation, PML/RARA t(15;17) translocation, CBFB rearrangement (inversion 16), BCR/ABL t(9;22) translocation. If three copies of RUNX1 are found in the RUNX1T1 translocation, the RUNX1 (21q22) rearrangement is performed at an additional charge (CPT code(s): 88271, 88275).


Instructions
Peripheral Blood in a lavender top (EDTA) tube and/or a green top sodium heparin tube.

OR

Bone Marrow in a lavender top (EDTA) tube and/or a green top sodium heparin tube.


Transport Container
Submit 5-10 mL Blood in a lavender top and/or 5-10 mL Blood in a green top.

OR

Submit 2-3 mL Bone Marrow in a lavender top and/or 2-3 mL Bone Marrow in a green top.

Do not centrifuge.


Transport Temperature
Refrigerated.


Specimen Stability
Ambient: 48 hours; Refrigerated: 15 days; Frozen: Unacceptable


Methodology
Next Generation Sequencing, PCR and Fragment Analysis, Fluorescence in situ hybridization (FISH), and for CEBPA only Next Generation Sequencing at Quest Diagnostics San Juan Capistrano Laboratory

Setup Schedule
Monday & Thursday


Report Available
10-14 days


Reference Range
An integrated report with results from all tests along with relevant diagnostic, prognostic and clinical trial information.


Clinical Significance
Helps physicians diagnose and predict the course of disease progression for hematologic diseases.


Performing Laboratory
med fusion; CEBPA Quest SJC



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.