AML Profile : 1016111

Test Code
MDFCPAMLPRO or 1016111

Alias/See Also
Acute Myeloid Leukemia; AML; Acute Promyelocytic Leukemia; APL; AML-M3; ASXL1; c-KIT; DNMT3A; ETV6 (TEL); FLT3; IDH1; IDH2; KRAS; NPM1; NRAS; PHF6; PTEN; RUNX1; SF3B1; SRSF2; TET2; TP53; U2AF1; WT1; CEBPA; FLT3-ITD-TKD; MLL(11q23); RUNX1T1/RUNX1 t(8;21); PML/RARA t(15;17); CBFB (inversion 16); BCR/ABL t(9;22)

CPT Codes
81450, 88271x10, 88275x5

Includes: Molecular: ASXL1, CEBPA, DNMT3A, ETV6 (TEL), FLT3, FLT3-ITD, IDH1, IDH2, KIT, KRAS, NPM1, NRAS, PHF6, PTEN, RUNX1, SF3B1, SRSF2, TET2, TP53, U2AF1, WT1 Cytogentic: MLL (11q23) rearrangement, RUNX1T1(ETO)/RUNX1(AML1) t(8;21) translocation, PML/RARA t(15;17) translocation, CBFB rearrangement (inversion 16), BCR/ABL t(9;22) translocation. If three copies of RUNX1 are found in the RUNX1T1 translocation, the RUNX1 (21q22) rearrangement is performed at an additional charge (CPT code(s): 88271, 88275).

Peripheral Blood in a lavender top (EDTA) tube and/or a green top sodium heparin tube.


Bone Marrow in a lavender top (EDTA) tube and/or a green top sodium heparin tube.

Transport Container
Submit 5-10 mL Blood in a lavender top and/or 5-10 mL Blood in a green top.


Submit 2-3 mL Bone Marrow in a lavender top and/or 2-3 mL Bone Marrow in a green top.

Do not centrifuge.

Transport Temperature

Specimen Stability
Ambient: 48 hours; Refrigerated: 15 days; Frozen: Unacceptable

Next Generation Sequencing, Fluorescence in situ hybridization (FISH) and Sanger Sequencing (for CEBPA only)

Setup Schedule
Monday & Thursday

Report Available
8-10 days

Reference Range
An integrated report with results from all tests along with relevant diagnostic, prognostic and clinical trial information.

Clinical Significance
Helps physicians diagnose and predict the course of disease progression for hematologic diseases.

Performing Laboratory
med fusion; FLT3 LabPMM; CEBPA Quest SJC

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.