MSH6, IHC with Interpretation

Test Code

MDFCPIHC16938 or 16938

CPT Codes
88342

Preferred Specimen

Formalin-fixed, paraffin-embedded tissue in IHC specimen transport kit

Other Acceptable Specimens

Unstained charged(+) slides (x5)

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Specimen other than paraffin block or slide

Methodology
Immunohistochemical Stain

Setup Schedule

Mon-Sat

Report Available

2-3 days

Reference Range

See Laboratory Report

Clinical Significance

Hereditary non-polyposis colorectal carcinoma (HNPCC) is associated with early onset carcinoma of colorectum, endometrium, small bowel, renal pelvis and ureter, ovary, hepatobiliary system, brain, and skin. 90% of patients with HNPCC have mutations of either MLH1 or MSH2; most of the remainder have mutations of PMS2 or MSH6. HNPCC in women confers a 42% to 60% lifetime probability of developing endometrial carcinoma. MSH6 is a mismatch repair gene which is deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition known as HNPCC.

Performing Laboratory
AmeriPath, Texas

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.