Lynch Syndrome Tumor Panel, IHC with Interpretation

Test Code

MDFCPIHC91332 or 91332

CPT Codes
88342, 88341 (x3)

Preferred Specimen

1 formalin-fixed, paraffin-embedded tissue block in an IHC specimen transport kit

Other Acceptable Specimens

10 unstained, positively charged slides submitted in an IHC specimen transport kit

Instructions

Tumor paraffin-block (formalin-fixed only) or five 4-micron unstained sections on Poly-L-Lysine or silane-coated slides. Please submit stained H&E slide and a copy of the pathology report.

Do not place paper labels with adhesive backing on slides. Use pencil or xylene-resistant pen to write on the frosted end of the slide only.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Do not reject. Send to lab for testing assessment. See Collection Instructions.

Methodology
Immunohistochemistry

Setup Schedule

Mon-Sat

Report Available

2-3 days

Reference Range

See Laboratory Report

Clinical Significance

Genetic defects in these four mismatch repair proteins underlie most cases of Lynch syndrome or hereditary non-polyposis colorectal carcinoma (HNPCC). This IHC panel looks for loss of expression of one or more of these proteins in cases of suspected HNPCC in tumor tissues from colorectal carcinomas, endometrial carcinomas, sebaceous adenoma/carcinoma or other adnexal tumors. If IHC results are abnormal, guidance is provided in the report on the recommended next step in the workup.

Performing Laboratory
AmeriPath, Texas

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.