Dihydropyrimidine Dehydrogenase (DPYD) Genotype

Test Code

DPYDGT or 18573

CPT Codes
81232

Preferred Specimen

5 mL whole blood collected in an EDTA (lavender-top) tube

Patient Preparation
Saliva: Do NOT eat, drink, smoke or chew gum for 30 minutes before collection. Do NOT remove the plastic film from the funnel lid.
Buccal: Do NOT eat, drink, smoke or chew gum for 30 minutes before collection. Do NOT touch swab or allow contact with any other object.

Minimum Volume

2 mL

Other Acceptable Specimens

Whole blood collected in an ACD (yellow-top) tube or
4 mL (3 mL minimum) saliva collected in an OGD-500 or
OGD-600 Oragene-Dx or 1 buccal swab (1 swab minimum) collected in an OCD100A, ORAcollect-Dx DNA collection kit

Transport Temperature

Room temperature

Specimen Stability

Whole Blood
Room temperature: 30 days
Refrigerated: 8 days
Frozen: Unacceptable

Saliva and Buccal
Room temperature: 30 days
Refrigerated: 30 days
Frozen: 30 days

Methodology
Microarray, Real-Time Polymerase Chain Reaction

Setup Schedule

Mon, Tues, Thurs, Sat

Report Available

8-24 days

Reference Range

See Laboratory Report

Clinical Significance

Dihydropyrimidine dehydrogenase, an enzyme encoded by the DPYD gene, is responsible for metabolizing fluoropyrimidines (5-fluorouracil (5-FU) and capecitabine) which are chemotherapeutic drugs frequently used to treat many types of cancer, including colorectal, breast, and cancers of the aerodigestive tract. Germline variants in DPYD affect enzyme production, which may result in an increased risk of significant, potentially fatal toxicity.

Performing Laboratory
Quest Diagnostics

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.