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Oropouche Virus Antibody (IgM)
Message**This test is not available for New York patient testing**
Test Code
ORVAMQ or 16766
CPT Codes
86790
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis; lipemic; icteric
Methodology
Immunoassay
Setup Schedule
Thursday
Report Available
1-7 days (from receipt at performing lab)
Reference Range
Not Detected
Clinical Significance
This immunoassay is intended for the qualitative detection of IgM antibodies to Oropouche virus in serum from patients suspected of having acute infection. A positive IgM result can help support diagnosis in a patient with the appropriate risk factors presenting with signs and symptoms consistent with Oropouche virus disease (Oropouche fever). If additional testing is needed, please contact the public health department.
Oropouche virus disease is a vector-borne infectious disease that is primarily transmitted through the bite of an infected midge or mosquito. The disease is primarily found in South America and the Caribbean. Increasing cases have been observed, including in US travelers, due to several outbreaks occurring outside known endemic areas. Symptomatic individuals typically present with fever, severe headache, chills, muscle aches, and joint pain with relapsing symptoms. These symptoms may overlap with other vector-borne illnesses in the same geographic regions, such as dengue, chikungunya, zika, or malaria. Complications related to neuroinvasive disease, Guillain-Barre syndrome, and vertical transmission in pregnant women have been reported.
Although there is no specific treatment for Oropouche virus disease, diagnostic testing is recommended to inform clinical management. Viremia is highest during the first 7 days post symptom onset, therefore direct detection of viral RNA using a molecular assay should be performed during this timeframe. Antibodies are typically detected starting 1 week post symptom onset. False negatives can occur early during infection before seroconversion; therefore, paired acute (within 2 weeks of illness) and convalescent sera can be tested.
Reference:
1. Wesselmann K, et al. Lancet infectious Diseases. 2024;24 :e439-452
2. Updated Interim Guidance for Health Departments on Testing and Reporting for Oropouche Virus Disease. https://www.cdc.gov/oropouche/php/reporting/index.html Last updated April 10, 2025.
Oropouche virus disease is a vector-borne infectious disease that is primarily transmitted through the bite of an infected midge or mosquito. The disease is primarily found in South America and the Caribbean. Increasing cases have been observed, including in US travelers, due to several outbreaks occurring outside known endemic areas. Symptomatic individuals typically present with fever, severe headache, chills, muscle aches, and joint pain with relapsing symptoms. These symptoms may overlap with other vector-borne illnesses in the same geographic regions, such as dengue, chikungunya, zika, or malaria. Complications related to neuroinvasive disease, Guillain-Barre syndrome, and vertical transmission in pregnant women have been reported.
Although there is no specific treatment for Oropouche virus disease, diagnostic testing is recommended to inform clinical management. Viremia is highest during the first 7 days post symptom onset, therefore direct detection of viral RNA using a molecular assay should be performed during this timeframe. Antibodies are typically detected starting 1 week post symptom onset. False negatives can occur early during infection before seroconversion; therefore, paired acute (within 2 weeks of illness) and convalescent sera can be tested.
Reference:
1. Wesselmann K, et al. Lancet infectious Diseases. 2024;24 :e439-452
2. Updated Interim Guidance for Health Departments on Testing and Reporting for Oropouche Virus Disease. https://www.cdc.gov/oropouche/php/reporting/index.html Last updated April 10, 2025.
Performing Laboratory
Quest
