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Oropouche Virus RNA, Qualitative Real-Time Reverse Transcriptase (RT) PCR
Test CodeOPOPVQ or 14328
Alias/See Also
Oropouche Fever * Arbovirus * Orthobunyavirus * Madre de Dios Virus * Iquitos Virus * Perdoes Virus *
OROV
OROV
CPT Codes
87798
Preferred Specimen
1.5 mL serum
Minimum Volume
0.5 mL
Other Acceptable Specimens
CSF
Transport Container
Plastic, sterile, leak-proof container
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Samples using heparin as anticoagulant
Methodology
Real-Time Reverse Transcriptase Polymerase Chain Reaction
Setup Schedule
Daily
Report Available
1-2 days from receipt at performing lab
Reference Range
Not detected
Clinical Significance
This test is intended for the detection of Oropouche virus (OROV) RNA in serum or CSF from patients
with exposure, signs or symptoms consistent with OROV infection. It can be used to help in the
diagnosis of Oropouche fever infection during the acute phase of the disease, which is typically within 7
days post-symptom onset. Serological testing can be considered for confirmatory diagnosis during the
convalescent phase of this disease (greater than 7 days). This molecular test cannot distinguish
between closely related reassortant OROVs within the Orthobunyavirus genus including Madre de Dios
Virus, Iquitos Virus and Perdoes Virus. The results of this test should be interpreted in the context of
pertinent clinical findings and history.
Reference:
1. Wesselmann K, et al. Lancet infectious Diseases. 2024;24:e439-452
with exposure, signs or symptoms consistent with OROV infection. It can be used to help in the
diagnosis of Oropouche fever infection during the acute phase of the disease, which is typically within 7
days post-symptom onset. Serological testing can be considered for confirmatory diagnosis during the
convalescent phase of this disease (greater than 7 days). This molecular test cannot distinguish
between closely related reassortant OROVs within the Orthobunyavirus genus including Madre de Dios
Virus, Iquitos Virus and Perdoes Virus. The results of this test should be interpreted in the context of
pertinent clinical findings and history.
Reference:
1. Wesselmann K, et al. Lancet infectious Diseases. 2024;24:e439-452
Performing Laboratory
Quest
