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FISH, IGH/BCL3, T(14;19) : 1017637
Test CodeMDFCPIGHBCL3 or 1017637
Alias/See Also
FISH, CLL, SLL, Lymphoma, Chronic lymphocytic leukemia, Small lymphocytic leukemia, B-cell lymphoproliferative disorder, Fluorescence in situ hybridization
CPT Codes
88271x2, 88275
Instructions
5 mL (3 mL minimum) Whole Blood or 3 mL (1 mL minimum) Bone Marrow in a Sodium Heparin (green top) tube.
Clinical history and reason for referral are required with test order. Prior therapy and bone marrow transplant history should be provided with test order.
Clinical history and reason for referral are required with test order. Prior therapy and bone marrow transplant history should be provided with test order.
Transport Container
Preferred Specimen: Sodium heparin (green top) tube
Alternative Specimen: EDTA (lavender top) tube
Alternative Specimen: EDTA (lavender top) tube
Transport Temperature
Room Temperature.
Specimen Stability
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. **Do not reject**
Methodology
Fluorescence in situ Hybridization (FISH)
Setup Schedule
Sunday - Saturday
Report Available
Up to 7 days
Limitations
This test was developed and its analytical performance characteristics have been determined by med fusion. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Reference Range
See Laboratory Report.
Clinical Significance
IGH/BCL3, t(14;19), rearrangement has been associated with B-cell lymphoproliferative neoplasms including occasional cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). It has been associated with lymphocytosis, atypical immunophenotype and lymphocyte morphology, unmutated IGHV gene, and an aggressive clinical course in CLL/SLL.
Performing Laboratory
med fusion