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IGH/MAFB translocation, t(14;20) by FISH : 1016990
Test CodeMDFCPCIGHMAFB or 1016990
Alias/See Also
Monoclonal Gammopathy of Unknown Significance (MGUS), Plasma Cell Myeloma
CPT Codes
88271x2, 88275
Instructions
3 mL bone marrow collected in a sodium heparin (green-top) tube
Minimum Volume: 1 mL
Minimum Volume: 1 mL
Transport Container
Preferred: Sodium heparin (green-top) tube
Alternative Specimen(s): Sodium heparin (royal blue-top) tube, Sodium heparin lead-free (tan-top) tube, or culture transport medium
Alternative Specimen(s): Sodium heparin (royal blue-top) tube, Sodium heparin lead-free (tan-top) tube, or culture transport medium
Transport Temperature
Room temperature.
Specimen Stability
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. **Do not reject**
Methodology
Fluorescence in situ Hybridization (FISH)
Setup Schedule
Sunday - Saturday
Report Available
Up to 7 days
Limitations
This test was developed and its analytical performance characteristics have been determined by med fusion. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Reference Range
See Laboratory Report.
Clinical Significance
The IGH-MAFB probe set is used to detect the t(14;20)(q32;q12) in patients with high-risk plasma cell myeloma (PCM). This translocation is strongly associated with del(13q), hypodiploid, and gain of 1q. However, patients with t(14;20) and monoclonal gammopathy, MGUS, or smoldering PCM, may have stable disease for years before progressing.
Performing Laboratory
med fusion
