Mycophenolic Acid : 10662

Test Code
MYCPA or 10662


CPT Codes
80180

Instructions
Serum: Collect blood in a red-top tube (no gel). Allow blood to clot at 15-28° C for 20-30 minutes. Centrifuge at 25-28° C (2200-2500 rpm, 1000 x g) for 8-10 minutes. Transfer serum to polypropylene or polyethylene transport tube. Ship refrigerated (cold packs). Samples left at room temperature for more than 3 days are not acceptable.
    
Plasma: Draw blood into an EDTA (lavender-top) tube. Separate cells by centrifugation at 18-25° C (2500-2800 rpm) for 5-10 minutes. Transfer plasma to polypropylene or polyethylene transport tube. Ship refrigerated (cold packs). Samples left at room temperature for more than 3 days are not acceptable.
   
Note: Optimum time to collect sample: 0.5 to 1 hour before next dose (trough) at steady-state (3-5 days after treatment with oral doses).


Transport Container
Preferred Specimen
1 mL serum collected in a red-top tube (no gel)

Minimum Volume
0.5 mL

Alternative
Plasma collected in Sodium heparin (green-top) tube or EDTA (lavender-top)  


Transport Temperature
Refrigerated.


Specimen Stability
Room temperature: 72 hours; Refrigerated: 14 days; Frozen: 60 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis, Lipemia, Improperly labeled specimens, Specimens left at room temperature >72 hours, Gel barrier/serum separator tube (SST)


Methodology
Chromatography/Mass Spectrometry

Setup Schedule
Monday - Saturday


Report Available
2-3 days


Reference Range
Mycophenolic Acid       1.0-3.5 mcg/mL
MPA Glucuronide          35.0-100.0 mcg/mL


Clinical Significance
Mycophenolic acid is an immunosuppressant used in tissue transplants. It prevents graft rejection by the host's immune system. It is important to monitor its level. Too little of this drug will cause graft rejection, while too much will lead to infection. Monitoring is essential to optimize therapeutic effects, avoid toxicity, and assure compliance.


Performing Laboratory
med fusion



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.