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Mycophenolic Acid : 10662
Test CodeMYCPA or 10662
CPT Codes
80180
Instructions
Serum: Collect blood in a red-top tube (no gel). Allow blood to clot at 15-28° C for 20-30 minutes. Centrifuge at 25-28° C (2200-2500 rpm, 1000 x g) for 8-10 minutes. Transfer serum to polypropylene or polyethylene transport tube. Ship refrigerated (cold packs). Samples left at room temperature for more than 3 days are not acceptable.
Plasma: Draw blood into an EDTA (lavender-top) tube. Separate cells by centrifugation at 18-25° C (2500-2800 rpm) for 5-10 minutes. Transfer plasma to polypropylene or polyethylene transport tube. Ship refrigerated (cold packs). Samples left at room temperature for more than 3 days are not acceptable.
Note: Optimum time to collect sample: 0.5 to 1 hour before next dose (trough) at steady-state (3-5 days after treatment with oral doses).
Plasma: Draw blood into an EDTA (lavender-top) tube. Separate cells by centrifugation at 18-25° C (2500-2800 rpm) for 5-10 minutes. Transfer plasma to polypropylene or polyethylene transport tube. Ship refrigerated (cold packs). Samples left at room temperature for more than 3 days are not acceptable.
Note: Optimum time to collect sample: 0.5 to 1 hour before next dose (trough) at steady-state (3-5 days after treatment with oral doses).
Transport Container
Preferred Specimen
1 mL serum collected in a red-top tube (no gel)
Minimum Volume
0.5 mL
Alternative
Plasma collected in Sodium heparin (green-top) tube or EDTA (lavender-top)
1 mL serum collected in a red-top tube (no gel)
Minimum Volume
0.5 mL
Alternative
Plasma collected in Sodium heparin (green-top) tube or EDTA (lavender-top)
Transport Temperature
Refrigerated.
Specimen Stability
Room temperature: 72 hours; Refrigerated: 14 days; Frozen: 60 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis, Lipemia, Improperly labeled specimens, Specimens left at room temperature >72 hours, Gel barrier/serum separator tube (SST)
Methodology
Chromatography/Mass Spectrometry
Setup Schedule
Monday - Saturday
Report Available
2-3 days
Reference Range
Mycophenolic Acid 1.0-3.5 mcg/mL
MPA Glucuronide 35.0-100.0 mcg/mL
MPA Glucuronide 35.0-100.0 mcg/mL
Clinical Significance
Mycophenolic acid is an immunosuppressant used in tissue transplants. It prevents graft rejection by the host's immune system. It is important to monitor its level. Too little of this drug will cause graft rejection, while too much will lead to infection. Monitoring is essential to optimize therapeutic effects, avoid toxicity, and assure compliance.
Performing Laboratory
med fusion