Disaccharidases : 19701

Test Code

DISACC or 19701

CPT Codes
82657x4

Includes

Lactase, Maltase, Palatinase, Sucrase

Instructions

Place 5 mg small bowel biopsy on the interior surface of a 2 mL polypropylene screw-cap cryovial or small polypropylene collection tube. Freeze within 2 hours of collection at -20° C.

Transport Container

Preferred Specimen
5 mg frozen small bowel biopsy collected in a 2 mL cryovial polypropylene screw-cap tube

Minimum Volume
2 mg

Transport Temperature

Frozen.

Specimen Stability

Room temperature: Unacceptable; Refrigerated: Unacceptable; Frozen: 31 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Received room temperature; Received refrigerated; Samples frozen later than 2 hours post-collection; Samples received in urine containers; Samples immersed in a colorless fluid (i.e., water, formalin, saline, etc.); Samples placed on gauze, filter paper or any other type of support media

Methodology
Spectrophotometry

Setup Schedule

Sunday - Friday

Report Available

1-3 days (from receipt at performing laboratory)

Limitations

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range

Lactase 15.0-45.5 uM/min/g prot

Sucrase 25.0-69.9 uM/min/g prot

Maltase 100.0-224.4 uM/min/g prot

Palatinase 5.0-26.3 uM/min/g prot

Clinical Significance

Lactase, maltase, palatinase and sucrase are mucosal disaccharidases that are present in normal small intestine and fetal colon. A decrease in the enzyme activity of these disaccharidases has been noted in colonic adenomas, adenocarcinomas and malabsorption. Decreased disaccharidase activity is a good indication of mucosal injury with the exception of lactase.

Performing Laboratory
Quest Diagnostics

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.