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Disaccharidases : 19701
Test CodeDISACC or 19701
CPT Codes
86257x4
Includes
Lactase, Maltase, Palatinase, Sucrase
Instructions
Place 5 mg small bowel biopsy on the interior surface of a 2 mL polypropylene screw-cap cryovial or small polypropylene collection tube. Freeze within 2 hours of collection at -20° C.
Transport Container
Preferred Specimen
5 mg frozen small bowel biopsy collected in a 2 mL cryovial polypropylene screw-cap tube
Minimum Volume
2 mg
5 mg frozen small bowel biopsy collected in a 2 mL cryovial polypropylene screw-cap tube
Minimum Volume
2 mg
Transport Temperature
Frozen.
Specimen Stability
Room temperature: Unacceptable; Refrigerated: Unacceptable; Frozen: 31 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature; Received refrigerated; Samples frozen later than 2 hours post-collection; Samples received in urine containers; Samples immersed in a colorless fluid (i.e., water, formalin, saline, etc.); Samples placed on gauze, filter paper or any other type of support media
Methodology
Spectrophotometry
Setup Schedule
Sunday - Friday
Report Available
1-3 days (from receipt at performing laboratory)
Reference Range
Lactase 15.0-45.5 uM/min/g prot
Sucrase 25.0-69.9 uM/min/g prot
Maltase 100.0-224.4 uM/min/g prot
Palatinase 5.0-26.3 uM/min/g prot
Clinical Significance
Lactase, maltase, palatinase and sucrase are mucosal disaccharidases that are present in normal small intestine and fetal colon. A decrease in the enzyme activity of these disaccharidases has been noted in colonic adenomas, adenocarcinomas and malabsorption. Decreased disaccharidase activity is a good indication of mucosal injury with the exception of lactase.
Performing Laboratory
Quest Diagnostics
