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Tacrolimus and Sirolimus, LC/MS/MS : 70006
Test CodeTACSIR or 70006
Alias/See Also
FK506 and Rapamycin
CPT Codes
80195, 80197
Includes
Tacrolimus and Sirolimus
Instructions
Collect specimen 1 hour prior to next dose (12 hour trough)
Transport Container
Specimen
4 mL whole blood collected in an EDTA (lavender-top) tube
Minimum Volume
2 mL
4 mL whole blood collected in an EDTA (lavender-top) tube
Minimum Volume
2 mL
Transport Temperature
Room temperature.
Specimen Stability
Room temperature: 5 days; Refrigerated: 7 days; Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Clotted Specimen
Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Setup Schedule
Monday - Saturday
Report Available
1-2 days
Reference Range
Tacrolimus
No definitive therapeutic or toxic ranges have been established. Optimal blood drug levels are influenced by type of transplant, patient response, time post-transplant, co-administration of other drugs, and drug formulation.The following trough range is a suggested guideline: 5.0-20.0 mcg/L
Sirolimus Trough: 3.0-18.0 mcg/L
Clinical Significance
Tacrolimus (FK506) and Sirolimus (Rapamycin) are immunosuppressive drugs used in organ transplantation to prevent graft rejection. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity.
Performing Laboratory
med fusion