Tacrolimus and Sirolimus, LC/MS/MS : 70006

Test Code

TACSIR or 70006

Alias/See Also

FK506 and Rapamycin

CPT Codes
80195, 80197

Includes

Tacrolimus and Sirolimus

Instructions

Collect specimen 1 hour prior to next dose (12 hour trough)

Transport Container

Specimen
4 mL whole blood collected in an EDTA (lavender-top) tube

Minimum Volume
2 mL

Transport Temperature

Room temperature.

Specimen Stability

Room temperature: 5 days; Refrigerated: 7 days; Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Clotted Specimen

Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Setup Schedule

Monday - Saturday

Report Available

1-2 days

Reference Range

Tacrolimus

No definitive therapeutic or toxic ranges have been established. Optimal blood drug levels are influenced by type of transplant, patient response, time post-transplant, co-administration of other drugs, and drug formulation.The following trough range is a suggested guideline: 5.0-20.0 mcg/L

Sirolimus Trough: 3.0-18.0 mcg/L

Clinical Significance

Tacrolimus (FK506) and Sirolimus (Rapamycin) are immunosuppressive drugs used in organ transplantation to prevent graft rejection. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity.

Performing Laboratory
med fusion

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.