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Sirolimus, LC/MS/MS : 36712
Test CodeSIRO or 36712
Alias/See Also
Rapamune® ,Rapamycin
CPT Codes
80195
Instructions
Collect specimen 1 hour prior to next dose (12 hour trough)
Transport Container
Specimen
2 mL whole blood collected in an EDTA (lavender-top) tube
Minimum Volume
1 mL
2 mL whole blood collected in an EDTA (lavender-top) tube
Minimum Volume
1 mL
Transport Temperature
Room temperature.
Specimen Stability
Room temperature: 5 days; Refrigerated: 7 days; Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Clotted Specimen
Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Setup Schedule
Monday - Saturday
Report Available
1-2 days
Reference Range
3.0-18.0 ng/mL
Clinical Significance
Sirolimus is an immunosuppressant drug used to prevent organ graft rejection. Therapeutic drug monitoring is used to optimize dose and avoid toxicity. Peak concentrations are reached in 2 hours following oral administration. Elimination half-life in males is approximately 72 hours; in females approximately 61 hours.
Performing Laboratory
med fusion
