Cyclosporine A Trough, LC/MS/MS, Blood : 15220

Test Code

CYCLO or 15520

CPT Codes
80158

Transport Container

Preferred Specimen
5 mL whole blood collected in an EDTA (lavender-top) tube

Alternative Specimen
Whole blood collected in: Sodium heparin (green-top) tube

Minimum Volume
2 mL

Transport Temperature

Room temperature.

Specimen Stability

Room temperature: 7 days; Refrigerated: 6 days; Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Clotted Specimen

Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Setup Schedule

Monday - Saturday

Report Available

1-3 days

Reference Range

No definitive therapeutic or toxic ranges have been established. Optimal blood drug levels are influenced by type of transplant, patient response, time post-transplant, co-administration of other drugs, and drug formulation.

The following trough ranges are suggested guidelines:

Kidney Transplantation 100-200 mcg/L

Other Organ Transplant 200-300 mcg/L

Clinical Significance

Cyclosporine is a commonly used immunosuppressive drug in patients receiving transplants. LC/MS/MS methods have higher specificity for the parent compound than immunoassay. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity. High cyclosporine levels can lead to nephrotoxicity; Low levels can lead to organ rejection following transplant. Peak concentrations are reached at around 3.5 hours after oral dosage. Elimination half-life is 10-27 hours.

Performing Laboratory
med fusion

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.