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Varicella Zoster Virus (VZV) DNA, Qualitative Real‐Time PCR : 34052
Test CodePTVZVL or 34052
CPT Codes
87798
Transport Container
Preferred Specimens
1 ml (0.3 ml minimum) whole blood collected in EDTA (lavender‐top) tube.
1 ml (0.3 ml minimum) CSF, bronchial lavage/brush/wash, collected in a sterile, plastic,leak‐proof container.
Lesion swab in VCM (green‐cap) tube or equivalent UTM or M4
0.5 mL (0.2 ml minimum) eye fluid (vitreous) in sterile, plastic, leak‐proof container
1 ml (0.3 ml minimum) whole blood collected in EDTA (lavender‐top) tube.
1 ml (0.3 ml minimum) CSF, bronchial lavage/brush/wash, collected in a sterile, plastic,leak‐proof container.
Lesion swab in VCM (green‐cap) tube or equivalent UTM or M4
0.5 mL (0.2 ml minimum) eye fluid (vitreous) in sterile, plastic, leak‐proof container
Transport Temperature
Refrigerated.
Specimen Stability
Whole blood
Room temperature: 48 hours; Refrigerated: 7 days; Frozen: Unacceptable
All other specimens
Room temperature: 48 hours; Refrigerated: 7 days; Frozen: 30 days
Room temperature: 48 hours; Refrigerated: 7 days; Frozen: Unacceptable
All other specimens
Room temperature: 48 hours; Refrigerated: 7 days; Frozen: 30 days
Methodology
Real‐Time Polymerase Chain Reaction
Setup Schedule
Monday - Saturday
Report Available
1-3 days
Reference Range
Not Detected
Clinical Significance
Varicella‐Zoster Virus DNA, Qualitative, Real‐Time PCR ‐This test is used for detection of Varicella-Zoster Virus (VZV) DNA in spectrum of clinical samples in individuals suspected or presenting with signs and symptoms of clinical VZV infection. Qualitative VZV PCR results can aid in diagnosis of cutaneous, subcutaneous and visceral varicella.
VZV is a member of the Herpesviridae family that causes two distinct clinical diseases in the infected individual. Varicella, or more commonly chickenpox, is the primary infection and is characterized by a generalized exanthematous rash. After primary infection, VZV characteristically becomes latent. Reactivation of the virus results in herpes zoster, or shingles, which is characterized by a vesicular rash limited to single dermatomes and is often, associated with pain and paresthesia. Noncutaneous sites of VZV involvement after chickenpox or reactivation most frequently involve the central nervous system (CNS) and are manifested as acute cerebellar ataxia, encephalitis, meningitis, transverse myelitis or Reye syndrome. Varicella pneumonitis is a serious complication of chickenpox that may be manifested as tachypnea, cough, dyspnea and fever. VZV infection in immunocompromised individuals often leads to a progressive disease state with involvement of multiple organs3, including the lungs, liver, eyes and central nervous system.
VZV is a member of the Herpesviridae family that causes two distinct clinical diseases in the infected individual. Varicella, or more commonly chickenpox, is the primary infection and is characterized by a generalized exanthematous rash. After primary infection, VZV characteristically becomes latent. Reactivation of the virus results in herpes zoster, or shingles, which is characterized by a vesicular rash limited to single dermatomes and is often, associated with pain and paresthesia. Noncutaneous sites of VZV involvement after chickenpox or reactivation most frequently involve the central nervous system (CNS) and are manifested as acute cerebellar ataxia, encephalitis, meningitis, transverse myelitis or Reye syndrome. Varicella pneumonitis is a serious complication of chickenpox that may be manifested as tachypnea, cough, dyspnea and fever. VZV infection in immunocompromised individuals often leads to a progressive disease state with involvement of multiple organs3, including the lungs, liver, eyes and central nervous system.
Performing Laboratory
med fusion
