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Cytochrome P450 2C9 Genotype
Test Code11294
Alias/See Also
LAB1351
CPT Codes
81227<br />
Physician Attestation of Informed Consent
This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.
Preferred Specimen
5 mL whole blood collected in an EDTA (lavender-top) tube
Minimum Volume
3 mL
Other Acceptable Specimens
Whole blood collected in: ACD solution B (yellow-top) tube or sodium heparin (green-top) tube
Instructions
Normal phlebotomy procedure. Specimen stability is crucial. Store and ship room temperature immediately. Do not freeze.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 8 days
Refrigerated: 8 days
Frozen: Unacceptable
Refrigerated: 8 days
Frozen: Unacceptable
Methodology
Polymerase Chain Reaction (PCR) • Single Nucleotide Primer Extension
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Thurs; Report available: 7-14 days
Limitations
The metabolism of drugs is influenced by genotype and other factors.
Reference Range
See Laboratory Report
Clinical Significance
This assay will detect the two major CYP2C9 alleles associated with poor drug metabolism and resultant drug toxicity or poor therapeutic response and may be used to obtain improved safety and efficacy data from clinical trials and to avoid adverse drug responses in clinical trial participants.
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |
