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Tropheryma whipplei DNA Qualitative,Real-Time PCR
Test Code11352
Alias/See Also
LAB15337
CPT Codes
87798<br>This test is for non-New York patient testing. For New York patient testing on tissue samples, see test code 900262.
Preferred Specimen
> 3 mm3 biopsy, submitted in a sterile, plastic leak-proof container, or
0.7 mL CSF collected in a sterile, plastic leak-proof container, or
0.7 mL whole blood collected in an EDTA (lavender-top) tube, or ACD solution B (yellow-top) tube
0.7 mL CSF collected in a sterile, plastic leak-proof container, or
0.7 mL whole blood collected in an EDTA (lavender-top) tube, or ACD solution B (yellow-top) tube
Minimum Volume
3 mm3 frozen tissue • 0.3 mL CSF or whole blood
Transport Temperature
Biopsy: Frozen
CSF and whole blood: Refrigerated (cold packs)
CSF and whole blood: Refrigerated (cold packs)
Specimen Stability
Biopsy and CSF
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 30 days
Whole blood
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: Unacceptable
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 30 days
Whole blood
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: Unacceptable
Methodology
Real-Time Polymerase Chain Reaction (RT-PCR)
Setup Schedule
Set up: Mon-Sat; Report available: 2-3 days
Reference Range
Not detected
Clinical Significance
Tropheryma whipplei (Whipple's disease) DNA, PCR is a highly sensitive and specific method to detect the presence of Tropheryma whipplei DNA in clinical specimens. The diagnosis of Tropheryma whipplei infection should not rely solely upon the result of a PCR assay. A positive result should be considered in conjunction with clinical presentation and additional established clinical tests. Moreover, this assay cannot differentiate between viable and nonviable organisms. A negative PCR result indicates the absence of Tropheryma whipplei DNA at detectable levels in the samples tested and does not exclude the diagnosis of disease.
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |
