A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

MGMT Promoter Methylation Tumor

Test Code
37374


Alias/See Also
LAB1234366


CPT Codes
81287

Preferred Specimen
Formalin-fixed paraffin-embedded tumor tissue block


Other Acceptable Specimens
5 unstained (minimum 5-micron thick sections) tumor slides (non-baked), and 1 H&E stained slide


Instructions
At least 40% tumor is required for this assay. In general, a 6 mm x 3 mm area of tissue cut at 5-micron thickness is the minimum amount of tissue needed. Tissue should be collected over multiple slides.

Note: When this test is ordered, slide review will always be performed at an additional charge (CPT 88381). Pathology report must accompany specimen in order for testing to be performed.

Submit one slide stained with hematoxylin and eosin and five unstained, nonbaked 5-micron thick sections of tumor


Transport Temperature
Room temperature


Specimen Stability
Room temperature: Varies
Refrigerated: Not established
Frozen: Not established


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Specimens that have been decalcified (all methods) • Specimens that have not been formalin-fixed, paraffin-embedded • Bone marrow in EDTA


Methodology
Methylation-Specific Polymerase Chain Reaction (PCR) Analysis

Setup Schedule
Set up: Varies (weekly); Report available: 7-10 days


Report Available
10 Days


Reference Range
Interpretive report


Clinical Significance
Prognostication of newly diagnosed glioblastomas. Identifying newly diagnosed glioblastomas that may respond to alkylating chemotherapy (ie, temozolomide). Guiding therapy decision making for newly diagnosed glioblastomas in elderly patients (>60 years).


Performing Laboratory
Mayo Clinic Laboratories
200 First Street SW
Rochester, MN 55905



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.