| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
5-Hydroxyindoleacetic Acid (5-HIAA), Random Urine with Creatinine
Test Code1648
Alias/See Also
LAB1231648
CPT Codes
82570, 83497
Includes
Creatinine
Preferred Specimen
10 mL random urine with 6N HCl submitted in a plastic, screw-cap container
Patient Preparation
Patient should avoid food high in indoles: avocado, banana, tomato, plum, walnut, pineapple, and eggplant
Minimum Volume
5 mL
Other Acceptable Specimens
Random urine, unpreserved, collected in a sterile screw-cap container
Instructions
After urine collection, add 6N HCl to maintain a pH below 3.
Urine without preservative is acceptable if pH is below 6 and the sample is shipped frozen.
Record patients age on test request form and urine vial.
Transport Temperature
Preserved: Room temperature
Unpreserved: Frozen
Unpreserved: Frozen
Specimen Stability
Room temperature: 7 days
Refrigerated: 30 days
Frozen: 30 days
Refrigerated: 30 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
pH >3.0 and received unfrozen
Methodology
High Performance Liquid Chromatography (HPLC) • Electrochemical Detection
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Monday-Friday Morning
Report available: 2 Days
Report available: 2 Days
Limitations
Patients with renal disease may display falsely decreased results. Urinary 5-HIAA is increased in patients with malabsorption disorders who also display a larger concentration of urinary tryptophan metabolites. Urinary 5-HIAA is increased in patients with intestinal obstruction and with some noncarcinoid islet cell tumors. Carcinoid syndrome may not cause elevated results, especially if the patient does not have diarrhea.
Reference Range
5-HIAA, Random Urine
Creatinine, Random Urine
| <2 Years | Not established | |
| 2-10 Years | ≤12.0 mg/g creat | |
| >10 Years | ≤10.0 mg/g creat | |
| ≤6 Months | 2-28 mg/dL | |
| 7-11 Months | 2-31 mg/dL | |
| 1-2 Years | 2-110 mg/dL | |
| 3-8 Years | 2-130 mg/dL | |
| 9-12 Years | 2-160 mg/dL | |
| >12 Years Male | 20-320 mg/dL | |
| >12 Years Female | 20-275 mg/dL | |
Clinical Significance
Values above 10 mg/24 hrs occur in carcinoid syndrome. Slight elevations also occur in nontropical sprue and after reserpine administration.
Drugs which can interfere with testing due to physiologic response: Acetaminophen, Alpha and Beta Blockers, Atenolol, Bromocriptine, Bronchodilators, Clonidine, Digoxin, Isoniazid, L-Dopa, Labetalol, Methyldopa, Monoamine Oxidase Inhibitors, Nitroglycerin, Sympathomimetic Amines, Phenobarbital, Phenothiazines, Phentolamine, Reserpine, Salicylates, Tricyclic Antidepressants
Drugs which can interfere with testing due to physiologic response: Acetaminophen, Alpha and Beta Blockers, Atenolol, Bromocriptine, Bronchodilators, Clonidine, Digoxin, Isoniazid, L-Dopa, Labetalol, Methyldopa, Monoamine Oxidase Inhibitors, Nitroglycerin, Sympathomimetic Amines, Phenobarbital, Phenothiazines, Phentolamine, Reserpine, Salicylates, Tricyclic Antidepressants
Performing Laboratory
Quest Diagnostics Nichols Inst San Juan Capistrano
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130
