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NKX3.1 IMMUNOHISTOCHEMISTRY (IHC)
MessageNote: This test is ordered by pathology in the laboratory information system
Test Code
NKX3
CPT Codes
88342-TC, primary, 88341-TC if additional IHC
Preferred Specimen
Tissue
Instructions
FDA Status
This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufactureer's instructions. Performance characteristics were verified by WVUH in a manner consisten with CLIA requirements.
Clinical Significance
Differentiating high-grade prostatic neoplasms from urothelial carcinoma, and evaluating tumors of unknown primary.
NKX3.1 is a prostate specific androgen-regulated homeobox gene located on chromosome 8p. NKX3.1 is a sensitive and specific tissue
marker of prostate adenocarcinoma. It is reported to be superior to PSA (prostate specific antigen) and PSAP (prostate specific acid
phosphatase) in both sensitivity and specificity. NKX3.1 may be useful in differentiating high-grade prostatic from urothelial carcinoma as well
as tumors of unknown primary. NKX3.1 a nuclear stain, but also typically shows a faint cytoplasmic blush in prostatic glandular cells. It
is expressed in both benign and neoplastic epithelium. It does not stain prostatic basal cells.
NKX3.1 is a prostate specific androgen-regulated homeobox gene located on chromosome 8p. NKX3.1 is a sensitive and specific tissue
marker of prostate adenocarcinoma. It is reported to be superior to PSA (prostate specific antigen) and PSAP (prostate specific acid
phosphatase) in both sensitivity and specificity. NKX3.1 may be useful in differentiating high-grade prostatic from urothelial carcinoma as well
as tumors of unknown primary. NKX3.1 a nuclear stain, but also typically shows a faint cytoplasmic blush in prostatic glandular cells. It
is expressed in both benign and neoplastic epithelium. It does not stain prostatic basal cells.
Performing Laboratory
West Virginia University Hospital, Inc.
