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NEUROFILAMENT PROTEIN (NFP) IMMUNOHISTOCHEMISTRY (IHC)
Test Code1230300845
CPT Codes
88342-T (primary), 88341-TC (if additional IHC)
Preferred Specimen
Tissue
Instructions
Note: This test is ordered by pathology in the CoPath laboratory information system
Methodology
Immunohistochemistry (IHC)
FDA Status
This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by WVUH in a manner consistent with CLIA requirements.
Clinical Significance
In some pathological conditions, neurofilaments can accumulate in large numbers within cell bodies and proximal axons of affected
neurons. In patients with amyotrophic lateral sclerosis (ALS), these accumulations are a hallmark pathological lesion, but they are also
prominent in sufferers of other neurological diseases, such as Charco- Marie-Tooth disease, giant axonal neuropathy, and diabetic
neuropathy to name a few, and are present in those people that suffer from Alzheimer’s disease and Parkinson’s disease.
neurons. In patients with amyotrophic lateral sclerosis (ALS), these accumulations are a hallmark pathological lesion, but they are also
prominent in sufferers of other neurological diseases, such as Charco- Marie-Tooth disease, giant axonal neuropathy, and diabetic
neuropathy to name a few, and are present in those people that suffer from Alzheimer’s disease and Parkinson’s disease.
Performing Laboratory
West Virginia University Hospital, Inc.
