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BETA-2 GLYCOPROTEIN 1 ANTIBODIES, IGA, SERUM
MessageSecond-line, supportive testing in the evaluation of patients with suspected antiphospholipid syndrome (APS)
Test Code
LAB3045589
CPT Codes
86146
Preferred Specimen
Gold Top Tube
Pediatric : 2 Gold Top Microtainers
Pediatric : 2 Gold Top Microtainers
Other Acceptable Specimens
Red Top Tube
Instructions
Centrifuge within 1 hour of collection. Separate serum from Cells if Red Top Tube. Aliquot 0.5 mL serum
Required for testing: 0.5 mL
Required for testing: 0.5 mL
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated: 7 Days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Failure to fully fill tube.
Methodology
Multiplex Immunoassay
Reference Range
≤ 19 Units/ mL = Negative
≥20 Units/ mL = Positive
≥20 Units/ mL = Positive
Clinical Significance
Interpretive Information: Autoimmune serology results must be interpreted within the clinical context. While strongly positive results for IgG and IgM beta-2 glycoprotein 1 (beta-2 GP1) antibodies are listed among diagnostic criteria for antiphospholipid syndrome (APS), weakly-positive beta-2 GP1 antibodies and positive antibodies of the IgA isotype are not considered diagnostic. Beta-2 GP1 antibodies must be detected on 2
or more occasions at least 12 weeks apart to fulfill the laboratory diagnostic criteria for APS. IgA beta-2 GP1 antibody results ≥20 U/mL with negative IgG and IgM beta-2 GP1 antibody results are not diagnostic for APS. Detection of beta-2 GP1 antibodies is not affected by anticoagulant treatment.
or more occasions at least 12 weeks apart to fulfill the laboratory diagnostic criteria for APS. IgA beta-2 GP1 antibody results ≥20 U/mL with negative IgG and IgM beta-2 GP1 antibody results are not diagnostic for APS. Detection of beta-2 GP1 antibodies is not affected by anticoagulant treatment.
Performing Laboratory
West Virginia University Hospital, Inc.
