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PHOSPHOLIPID (CARDIOLIPIN) ANTIBODIES, IGG, SERUM
Test CodeLAB3045587
CPT Codes
86147
Preferred Specimen
Gold Top Tube
Pediatric: 2 Gold Top Microtainers
Pediatric: 2 Gold Top Microtainers
Minimum Volume
0.5mL Serum
Other Acceptable Specimens
Red Top Tube
Instructions
Centrifuge within 1 hour of collection. Separate serum from cells if Red Top Tube. Aliquot 0.5 mL serum.
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated: 7 Days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Failure to fully fill tube
Methodology
Multiplex Immunoassay
Reference Range
≤19 Units/ mL = Negative
≥20 Units/ mL = Positive
≥20 Units/ mL = Positive
Clinical Significance
Autoimmune serology results must be interpreted within clinical context.
Positive and strongly-positive results for IgG and IgM phospholipid (cardiolipin) antibodies (≥40 U/mL) are diagnostic criteria for antiphospholipid syndrome (APS). Lesser levels of IgG and IgM phospholipid (cardiolipin) antibodies (≥20 to <40 U/mL) and antibodies of the IgA isotype are not considered diagnostic. Phospholipid (cardiolipin) antibodies must be detected on 2 or more occasions at least 12 weeks apart to fulfill the laboratory diagnostic criteria for APS.
Detection of phospholipid antibodies is not affected by anticoagulant treatment.
Positive and strongly-positive results for IgG and IgM phospholipid (cardiolipin) antibodies (≥40 U/mL) are diagnostic criteria for antiphospholipid syndrome (APS). Lesser levels of IgG and IgM phospholipid (cardiolipin) antibodies (≥20 to <40 U/mL) and antibodies of the IgA isotype are not considered diagnostic. Phospholipid (cardiolipin) antibodies must be detected on 2 or more occasions at least 12 weeks apart to fulfill the laboratory diagnostic criteria for APS.
Detection of phospholipid antibodies is not affected by anticoagulant treatment.
Performing Laboratory
West Virginia University Hospital, Inc.
