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BETA-2 GLYCOPROTIEN 1 ANTIBODIES, IGG AND IGM, SERUM
MessageFirst-line, diagnostic testing in the evaluation of patients with suspected antiphospholipid syndrome (APS)
Test Code
LAB304362
CPT Codes
86146
Preferred Specimen
Gold Top Tube
Pediatric: 2 Gold Top Microtainers
Pediatric: 2 Gold Top Microtainers
Instructions
Centrifuge within 1 hour of collection. Separate serum from cells if Red Top Tube. Aliquot 0.5 mL serum
Required for Testing: 0.5 mL
Required for Testing: 0.5 mL
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated: 7 Days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Failure to fully fill the tube
Methodology
Multiplex Immunoassay
Reference Range
≤ 19 Units/ mL = Negative
≥ 20 Units/mL = Positive
≥ 20 Units/mL = Positive
Clinical Significance
Auotimmune serology results must be interpreted within the clinical context. Strongly positive results for beta-2 glycoprotein 1 (beta-2 GP1)
antibodies (>40 U/mL for IgG and/or IgM) are diagnostic criterion for APS. Lesser levels of beta-2 GP1 antibodies (≥20 to <40 U/mL) and
positive antibodies of the IgA isotype are not considered diagnostic. Beta-2 GP1 antibodies must be detected on 2 or more occasions at
least 12 weeks apart to fulfill the laboratory diagnostic criteria for APS. Detection of beta-2 GP1 antibodies is not affected by anticoagulant
treatment.
antibodies (>40 U/mL for IgG and/or IgM) are diagnostic criterion for APS. Lesser levels of beta-2 GP1 antibodies (≥20 to <40 U/mL) and
positive antibodies of the IgA isotype are not considered diagnostic. Beta-2 GP1 antibodies must be detected on 2 or more occasions at
least 12 weeks apart to fulfill the laboratory diagnostic criteria for APS. Detection of beta-2 GP1 antibodies is not affected by anticoagulant
treatment.
Performing Laboratory
West Virginia University Hospital, Inc.
