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PHOSPHOLIPID (CARDIOLIPIN) ANTIBODIES, IGA, SERUM
Test CodeLAB304221
CPT Codes
86147
Preferred Specimen
Gold Top Tube
Pediatric: 2 Gold Top Microtainers
Pediatric: 2 Gold Top Microtainers
Other Acceptable Specimens
Red Top Tube
Instructions
Centrifuge within 1 hour of collection. Separate serum from cells if Red Top Tube. Aliquot 0.5mL serum.
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated: 7 Days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Failure to fully fill tube.
Methodology
Multiplex Immunoassay
Reference Range
≤19 Units/mL = Negative
≥20 Units/mL = Postivie
≥20 Units/mL = Postivie
Clinical Significance
Autoimmune serology results must be interpreted within the clinical context.
Positive and strongly-positive results for IgG and IgM phospholipid (cardiolipin) antibodies (≥40 U/mL) are diagnostic criteria for antiphospholipid syndrome (APS). Lesser levels of IgG and IgM phospholipid (cardiolipin) antibodies (≥20 to <40 U/mL) and antibodies of the IgA isotype are not considered diagnostic. Phospholipid (cardiolipin) antibodies must be detected on 2 or more occasions at least 12 weeks apart to fulfill the laboratory diagnostic criteria for APS.
IgA phospholipid (cardiolipin) antibody results (≥20 U/mL) with negative IgG and IgM phospholipid (cardiolipin) antibody results are not diagnostic for APS.
Detection of phospholipid (cardiolipin) antibodies is not affected by anticoagulant treatment.
Positive and strongly-positive results for IgG and IgM phospholipid (cardiolipin) antibodies (≥40 U/mL) are diagnostic criteria for antiphospholipid syndrome (APS). Lesser levels of IgG and IgM phospholipid (cardiolipin) antibodies (≥20 to <40 U/mL) and antibodies of the IgA isotype are not considered diagnostic. Phospholipid (cardiolipin) antibodies must be detected on 2 or more occasions at least 12 weeks apart to fulfill the laboratory diagnostic criteria for APS.
IgA phospholipid (cardiolipin) antibody results (≥20 U/mL) with negative IgG and IgM phospholipid (cardiolipin) antibody results are not diagnostic for APS.
Detection of phospholipid (cardiolipin) antibodies is not affected by anticoagulant treatment.
Performing Laboratory
West Virginia University Hospital, Inc.
