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SYPHILIS TITER MONITORING
MessageUsed for serological monitoring of treatment response for patients with active syphilis. For general syphilis diagnostic testing on serum, see
Syphilis Dual Screening algorithm with reflex (LAB1230000)
Syphilis Dual Screening algorithm with reflex (LAB1230000)
Test Code
LAB1230621
CPT Codes
86593
Preferred Specimen
Gold Top Tube
Pediatric: 2 Gold Top Microtainers
Pediatric: 2 Gold Top Microtainers
Minimum Volume
0.5mL Serum
Other Acceptable Specimens
Red Top Tube
Instructions
Centrifuge within 1 hour of collection. Separate serum from cells if Red Top Tube. Aliquot 0.5mL serum
Transport Temperature
Refrigerated
Specimen Stability
2-8°C for 7 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Failure to fully fill tube
Methodology
Multiplex Immunoassay
Setup Schedule
Monday-Friday Dayshift, as needed
Clinical Significance
This offering of a stand-alone rapid plasma reagin/RPR test is intended for patients with known history of syphilis infection (which should consistently yield positive treponemal antibodies) and treatment, where monitoring for decline in RPR titer is needed.
This test should NOT be used as a primary diagnostic approach for syphilis.
Patients with primary or secondary syphilis should be re-tested no sooner than 6 months, and then 12 months, following treatment.
Typically, rapid plasma reagin (RPR) titers decrease following successful treatment, but this may occur over a period of months to years.
Treatment response is generally indicated by a 4-fold reduction in RPR titer (eg, from 1:32 to 1:8). For proper interpretation of RPR results, titers should be consistently tested at the same testing laboratory.
This test should NOT be used as a primary diagnostic approach for syphilis.
Patients with primary or secondary syphilis should be re-tested no sooner than 6 months, and then 12 months, following treatment.
Typically, rapid plasma reagin (RPR) titers decrease following successful treatment, but this may occur over a period of months to years.
Treatment response is generally indicated by a 4-fold reduction in RPR titer (eg, from 1:32 to 1:8). For proper interpretation of RPR results, titers should be consistently tested at the same testing laboratory.
Performing Laboratory
West Virginia University Hospital, Inc.
Additional Information
RPR Test Change Notification
