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CYTOPATHOLOGY, GYN, +/- High Risk HPV
MessageALL PATHOLOGY SPECIMENS MUST BE SUBMITTED WITH A PRINTED COPY OF THE ORDER
Test Code
LAB4
CPT Codes
88141- MD Review, 88175
Includes
Cytological evaluation of a thin prep made from cervical scraping, endocervical brushing, vaginal mucosa scraping. Clinician must indicate whether high-risk HPV testing is to be performed per ASCCP guidelines, regardless of diagnosis, areflex if ascus, or not at all. If per guidelines is requested, HPV testing will be performed in cases with a cytologic diagnosis of “ASCUS” (in patients 25 and older), and in cases with cytologic diagnosis of “Negative for intraepithelial lesion or malignancy” (in patients 30 and older, once per 5 calendar years). Testing algorithm may vary depending on other patient factors such as prior diagnoses or menopausal status
Preferred Specimen
PAP THIN PREP: One PreservCyt Solution Vial
Instructions
Patient should avoid douching forty-eight to seventy-two hours prior to examination. Sample the ectocervix using a
plastic spatula. Rinse the spatula into the PreservCyt Solution vial by swirling the spatula vigorously in the vial ten times. Sample the
endocervix using an endocervical brush. Rinse the brush in the same vial by rotating the device in the solution ten times while pushing
against the PreservCyt vial wall. Swirl the brush vigorously to further release material. Discard the brush and spatula. Securely tighten the
cap and label the vial with patient's name and hospital number. Include all pertinent history with paper requisition.
For Thin Prep pap smears, the clinician must indicate whether high-risk HPV testing is to be performed
per 2012 ASCCP guidelines, regardless of diagnosis, or not at all. More information is available at: www.asccp.org.
plastic spatula. Rinse the spatula into the PreservCyt Solution vial by swirling the spatula vigorously in the vial ten times. Sample the
endocervix using an endocervical brush. Rinse the brush in the same vial by rotating the device in the solution ten times while pushing
against the PreservCyt vial wall. Swirl the brush vigorously to further release material. Discard the brush and spatula. Securely tighten the
cap and label the vial with patient's name and hospital number. Include all pertinent history with paper requisition.
For Thin Prep pap smears, the clinician must indicate whether high-risk HPV testing is to be performed
per 2012 ASCCP guidelines, regardless of diagnosis, or not at all. More information is available at: www.asccp.org.
Transport Temperature
Ambient
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Unlabeled PreservCyt vial
Methodology
Manual Slide Review and ThinPrep Imager Duo
Setup Schedule
Monday-Friday
Clinical Significance
2012 ASCCP guidelines for cervical cancer screening with Pap and HPV tests take into account the patient’s age, cytology result,
pregnancy status, post-menopausal status, and cervical cytology and surgical pathology findings within the past few years. Management
recommendations are given per these guidelines. Current guidelines for cervical cancer screening are available at: http://www.cdc.gov/
cancer/cervical/pdf/guidelines.pdf, and management guidelines that take into account pap and HPV results (when performed) are available
at: http://www.asccp.org/ConsensusGuidelines/tabid/7436/Defaul\\t.aspx.
pregnancy status, post-menopausal status, and cervical cytology and surgical pathology findings within the past few years. Management
recommendations are given per these guidelines. Current guidelines for cervical cancer screening are available at: http://www.cdc.gov/
cancer/cervical/pdf/guidelines.pdf, and management guidelines that take into account pap and HPV results (when performed) are available
at: http://www.asccp.org/ConsensusGuidelines/tabid/7436/Defaul\\t.aspx.
Performing Laboratory
West Virginia University Hospital, Inc.
Berkeley Medical Center
Camden Clark Medical Center
United Hospital Center
